S
Shakir D. AlSharari
Researcher at Virginia Commonwealth University
Publications - 16
Citations - 287
Shakir D. AlSharari is an academic researcher from Virginia Commonwealth University. The author has contributed to research in topics: Nicotinic agonist & Colitis. The author has an hindex of 9, co-authored 16 publications receiving 218 citations. Previous affiliations of Shakir D. AlSharari include King Saud University & VCU Medical Center.
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Journal ArticleDOI
Novel Insights on the Effect of Nicotine in a Murine Colitis Model
Shakir D. AlSharari,Hamid I. Akbarali,Rehab A. Abdullah,Omer Shahab,Wimolnut Auttachoat,Gabriela A. Ferreira,Kimber L. White,Aron H. Lichtman,Guy A. Cabral,M. Imad Damaj +9 more
TL;DR: The results highlight that dose and route of administration play a critical role in the protective effect of nicotine in the DSS mouse colitis model, and cotinine alone failed to show a significant effect.
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The Antinociceptive Effects of Nicotinic Partial Agonists Varenicline and Sazetidine-A in Murine Acute and Tonic Pain Models
TL;DR: The results suggest that nicotinic partial agonists possess analgesic effects in a rodent tonic pain model and may provide a potential treatment for the treatment of chronic pain disorders.
Journal ArticleDOI
Expression and pharmacological modulation of visceral pain-induced conditioned place aversion in mice.
Deniz Bagdas,Deniz Bagdas,Pretal P. Muldoon,Shakir D. AlSharari,F. Ivy Carroll,S. Stevens Negus,M. Imad Damaj +6 more
TL;DR: A preclinical mouse model of pain-related aversive behavior that can be used to assess genetic and biological mechanisms of pain as well as improving the predictive validity of preclinical studies on candidate analgesics is characterized and validated.
Journal ArticleDOI
Ameliorative Potential of Morin in Streptozotocin-Induced Neuropathic Pain in Rats
Shakir D. AlSharari,Salim S. Al-Rejaie,Hatem M. Abuohashish,Mihir Y. Parmar,Mohammed M. Ahmed +4 more
TL;DR: The findings demonstrate the protective effect of morin mediated through reduction of oxidative stress and inflammatory process, and suggest the therapeutic potential of morIn in the attenuation of diabetic neuropathy.
Journal ArticleDOI
The interaction between alpha 7 nicotinic acetylcholine receptor and nuclear peroxisome proliferator-activated receptor-α represents a new antinociceptive signaling pathway in mice.
Giulia Donvito,Deniz Bagdas,Deniz Bagdas,Wisam Toma,Elnaz Rahimpour,Asti Jackson,Julie A. Meade,Shakir D. AlSharari,Abhijit R. Kulkarni,F. Ivy Carroll,Aron H. Lichtman,Roger L. Papke,Ganesh A. Thakur,M. Imad Damaj +13 more
TL;DR: It is found that PNU282987, a full PPAR‐&agr;7 agonist, attenuated formalin‐induced nociceptive behavior in &agR;7‐dependent manner and plays a key role in a putative antinociception and nicotinic signaling pathway.