S
Shalini Dogra
Researcher at Central Drug Research Institute
Publications - 26
Citations - 412
Shalini Dogra is an academic researcher from Central Drug Research Institute. The author has contributed to research in topics: Metabotropic glutamate receptor & Medicine. The author has an hindex of 9, co-authored 19 publications receiving 236 citations. Previous affiliations of Shalini Dogra include Council of Scientific and Industrial Research & Vanderbilt University.
Papers
More filters
Journal ArticleDOI
Core engagement with β-arrestin is dispensable for agonist-induced vasopressin receptor endocytosis and ERK activation
Punita Kumari,Ashish Srivastava,Eshan Ghosh,Ravi Ranjan,Shalini Dogra,Prem N. Yadav,Arun K. Shukla +6 more
TL;DR: For a prototypical GPCR, the human vasopressin receptor type 2 (V2R), βarr1 can form a stable complex associated via only the phosphorylated carboxyl terminus of the receptor that is functionally competent with respect to supporting receptor internalization and ERK MAPK activation.
Journal ArticleDOI
Biased agonism at kappa opioid receptors: Implication in pain and mood disorders.
Shalini Dogra,Prem N. Yadav +1 more
TL;DR: Various lines of evidence are highlighted, which indicates different ligands of k receptor as "biased", and their potential implications in mood and pain disorders.
Journal ArticleDOI
A synthetic intrabody-based selective and generic inhibitor of GPCR endocytosis.
Eshan Ghosh,Ashish Srivastava,Mithu Baidya,Punita Kumari,Hemlata Dwivedi,Kumari Nidhi,Ravi Ranjan,Shalini Dogra,Akiko Koide,Prem N. Yadav,Sachdev S. Sidhu,Shohei Koide,Arun K. Shukla +12 more
TL;DR: The data demonstrate the feasibility of selectively targeting βarr interactions using intrabodies and provide a novel framework for fine-tuning GPCR functions with potential therapeutic implications.
Journal ArticleDOI
Docosahexaenoic acid modulates brain-derived neurotrophic factor via GPR40 in the brain and alleviates diabesity-associated learning and memory deficits in mice.
Chandan Sona,Ajeet Kumar,Shalini Dogra,Boda Arun Kumar,Deepmala Umrao,Prem N. Yadav,Prem N. Yadav +6 more
TL;DR: Evidence is provided that DHA stimulation of GPR40 mediate some of DHA's beneficial effects in metabolic syndrome and identify G PR40 as a viable therapeutic target for the treatment of CNS-related comorbidities associated with diabesity.
Journal ArticleDOI
Acute restraint stress redirects prefrontal cortex circuit function through mGlu5 receptor plasticity on somatostatin-expressing interneurons
Max E. Joffe,James Maksymetz,Joseph R Luschinger,Shalini Dogra,Anthony S. Ferranti,Deborah J. Luessen,Isabel Gallinger,Zixiu Xiang,Hannah E. Branthwaite,Patrick R. Melugin,Kellie M. Williford,Samuel W. Centanni,Brenda C. Shields,Craig W. Lindsley,Erin S. Calipari,Cody A. Siciliano,Colleen M. Niswender,Michael R. Tadross,Danny G. Winder,P. Jeffrey Conn +19 more
TL;DR: The authors showed that mGlu5 receptor activation facilitates long-term potentiation at synapses from the basolateral amygdala (BLA) onto SST-INs in mice.