Shan Su

TL;DR: It has been speculated that RRAR, a unique furin-like cleavage site in the spike protein (S), which is absent in other lineage B βCoVs, such as SARS-CoV, is responsible for its high infectivity and transmissibility.

TL;DR: Examples of vaccine-associated disease enhancement in the history of developing vaccines against respiratory syncytial virus, dengue virus, SARS-CoV and Middle East respiratory syndrome coronavirus are summarized and recommended for preclinical and clinical evaluation of COVID-19 vaccine candidates as well as for vaccine design and optimization.

TL;DR: The most recent studies on the structure of the MERS-CoV spike protein and its role in virus binding and entry are discussed, and the development of Mers- coV entry/fusion inhibitors targeting the S1 subunit, particularly the receptor-binding domain (RBD), and the S2 sub unit, especially the HR1 region are looked at.

TL;DR: In this article, the development of antivirals with common targets, including those against the same protein across viruses, or the same viral function, was reviewed to provide clues for development of anti-viral drugs for future epidemics.

TL;DR: This review summarized the current knowledge on the advantages and disadvantages of the SARS-CoV vaccine candidates and prospected the strategies for the development of safe, effective and broad-spectrum coronavirus vaccines for prevention of infection by currently circulating SARS -CoV-2 and other emerging and reemerging coronaviruses that may cause future epidemics or pandemics.