There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.

Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

I and i

다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

This article explores recent advances in the design and engineering of materials wholly or principally constructed from peptides. We focus on materials that are able to respond to changes in their environment (pH, ionic strength, temperature, light, oxidation/reduction state, presence of small molecules or the catalytic activity of enzymes) by altering their macromolecular structure. Such peptide-based responsive biomaterials have exciting prospects for a variety of biomedical and bionanotechnology applications in drug delivery, bio-sensing and regenerative medicine.

Peptide-based stimuli-responsive biomaterials

The Physics of Rubber Elasticity (J. Meixner)

Nanogels and microgels are soft, deformable, and penetrable objects with an internal gel-like structure that is swollen by the dispersing solvent. Their softness and the potential to respond to external stimuli like temperature, pressure, pH, ionic strength, and different analytes make them interesting as soft model systems in fundamental research as well as for a broad range of applications, in particular in the field of biological applications. Recent tremendous developments in their synthesis open access to systems with complex architectures and compositions allowing for tailoring microgels with specific properties. At the same time state-of-the-art theoretical and simulation approaches offer deeper understanding of the behavior and structure of nano- and microgels under external influences and confinement at interfaces or at high volume fractions. Developments in the experimental analysis of nano- and microgels have become particularly important for structural investigations covering a broad range of length scales relevant to the internal structure, the overall size and shape, and interparticle interactions in concentrated samples. Here we provide an overview of the state-of-the-art, recent developments as well as emerging trends in the field of nano- and microgels. The following aspects build the focus of our discussion: tailoring (multi)functionality through synthesis; the role in biological and biomedical applications; the structure and properties as a model system, e.g., for densely packed arrangements in bulk and at interfaces; as well as the theory and computer simulation.

Nanogels and Microgels: From Model Colloids to Applications, Recent Developments, and Future Trends

https://onlinelibrary.wiley.com/doi/pdf/10.1002/adfm.201909359

Programmed Multiresponsive Hydrogel Assemblies with Light‐Tunable Mechanical Properties, Actuation, and Fluorescence

In this study a new pH-responsive nanogel probe containing a complementary nonradiative resonance energy transfer (NRET) fluorophore pair is investigated and its ability to act as a versatile probe of network-related changes in three hydrogels demonstrated. Fluorescent sensing using NRET is a powerful method for studying relationships between Angstrom length-scale structure and macroscopic properties of soft matter. Unfortunately, inclusion of NRET fluorophores into such materials requires material-specific chemistry. Here, low concentrations of preformed nanogel probes were included into hydrogel hosts. Ratiometric photoluminescence (PL) data for the gels labeled with the nanogel probes enabled pH-triggered swelling and deswelling to be studied as well as Ca2+-triggered collapse and solute release. PL measurements during compression of a nanogel probe-labeled nanocomposite gel demonstrated mechanochromic behavior and strain sensing. The new nanogel probes have excellent potential for investigating the in...

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Responsive Nanogel Probe for Ratiometric Fluorescent Sensing of pH and Strain in Hydrogels

The mesoporous (meso)-TiO2 layer is a key component of high-efficiency perovskite solar cells (PSCs). Herein, pore size controllable meso-TiO2 layers are prepared using spin coating of commercial TiO2 nanoparticle (NP) paste with added soft polymer templates (SPT) followed by removal of the SPT at 500 °C. The SPTs consist of swollen crosslinked polymer colloids (microgels, MGs) or a commercial linear polymer (denoted as LIN). The MGs and LIN were comprised of the same polymer, which was poly(N-isopropylacrylamide) (PNIPAm). Large (L-MG) and small (S-MG) MG SPTs were employed to study the effect of the template size. The SPT approach enabled pore size engineering in one deposition step. The SPT/TiO2 nanoparticle films had pore sizes > 100 nm, whereas the average pore size was 37 nm for the control meso-TiO2 scaffold. The largest pore sizes were obtained using L-MG. SPT engineering increased the perovskite grain size in the same order as the SPT sizes: LIN < S-MG < L-MG and these grain sizes were larger than those obtained using the control. The power conversion efficiencies (PCEs) of the SPT/TiO2 devices were ∼20% higher than that for the control meso-TiO2 device and the PCE of the champion S-MG device was 18.8%. The PCE improvement is due to the increased grain size and more effective light harvesting of the SPT devices. The increased grain size was also responsible for the improved stability of the SPT/TiO2 devices. The SPT method used here is simple, scalable, and versatile and should also apply to other PSCs.

https://cronfa.swan.ac.uk/Record/cronfa54160/Download/54160__17199__f59cd888cba44de09d260a0719d20b1c.pdf

Using Soft Polymer Template Engineering of Mesoporous TiO2 Scaffolds to Increase Perovskite Grain Size and Solar Cell Efficiency

Triply responsive coumarin-based microgels with remarkably large photo-switchable swelling

Microgels (MGs) are crosslinked polymer particles that swell when the pH approaches the pKa of the constituent polymer. Our earlier work showed that concentrated MG dispersions can be covalently interlinked to form macroscopic hydrogels, which are termed doubly crosslinked microgels (DX MGs). Here, we study for the first time the effects of intra-MG crosslinking on the swelling of the MGs and the mechanical properties of the DX MGs. The MGs were synthesised by emulsion copolymerisation of ethyl acrylate (EA) or methacrylic acid (MAA) and divinylbenzene (DVB). The latter was a crosslinking monomer. For comparison, MGs were prepared where DVB was replaced by either 1,4-butanediol diacrylate (BDDA) or a 1 : 1 mixture of both DVB and BDDA. The MG swelling behaviours were studied by dynamic light scattering; whereas, the DX MG mechanical properties were studied by dynamic rheology and uniaxial compression measurements. Inclusion of DVB within the MGs resulted in both highly swelling MGs and highly ductile DX MGs. The average strain-at-break value for the DVB-containing DX MGs was 76% which represents the highest value yet reported for a DX MG prepared using commercially available monomers. It was also shown that good tuneability of the DX MG properties could be obtained simply by controlling the DVB and BDDA contents within the MG particles. Analysis of the swelling and compression data enabled relationships between the volume-swelling ratio of the MGs and either the modulus or strain-at-break values for the DX MGs. These relationships also applied to a DVB-free system prepared with a low BDDA content. An interesting conclusion from this study is that the DX MGs can be thought of mechanically as macroscopic MG particles. The results of this study provide design tools for improving DX MG ductility and hence increasing the range of potential applications for this new class of hydrogel.

Shanglin Wu

Papers

Programmed Multiresponsive Hydrogel Assemblies with Light‐Tunable Mechanical Properties, Actuation, and Fluorescence

Responsive Nanogel Probe for Ratiometric Fluorescent Sensing of pH and Strain in Hydrogels

Using Soft Polymer Template Engineering of Mesoporous TiO2 Scaffolds to Increase Perovskite Grain Size and Solar Cell Efficiency

Triply responsive coumarin-based microgels with remarkably large photo-switchable swelling

Using intra-microgel crosslinking to control the mechanical properties of doubly crosslinked microgels