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Shanmugasundaram Ganapathy-Kanniappan
Researcher at Johns Hopkins University School of Medicine
Publications - 54
Citations - 2027
Shanmugasundaram Ganapathy-Kanniappan is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Cancer cell & Cancer. The author has an hindex of 19, co-authored 53 publications receiving 1546 citations. Previous affiliations of Shanmugasundaram Ganapathy-Kanniappan include Johns Hopkins University.
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Journal ArticleDOI
Tumor glycolysis as a target for cancer therapy: progress and prospects.
TL;DR: The objective of this review is to present the most recent research on the cancer-specific role of glycolysis including their non-glycolytic functions in order to explore the potential for therapeutic opportunities.
Journal ArticleDOI
A critical role for the host mediator macrophage migration inhibitory factor in the pathogenesis of malarial anemia
Michael A. McDevitt,Jianlin Xie,Shanmugasundaram Ganapathy-Kanniappan,Jason W. Griffith,Aihua Liu,Courtney McDonald,Philip E. Thuma,Victor R. Gordeuk,Christine N. Metz,Robert A. Mitchell,Jeffrey R. Keefer,John R. David,Lin Leng,Richard Bucala +13 more
TL;DR: An intrinsic role for macrophage migration inhibitory factor (MIF) is described in the development of the anemic complications and bone marrow suppression that are associated with malaria infection and polymorphisms at the MIF locus are suggested to influence the levels of MIF produced in the innate response to malaria infection.
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Molecular intricacies of aerobic glycolysis in cancer: current insights into the classic metabolic phenotype.
TL;DR: Accumulating data unequivocally demonstrate that aerobic glycolysis implicates myriad of molecular and functional processes to support cancer progression.
Journal ArticleDOI
3-Bromopyruvate: A New Targeted Antiglycolytic Agent and a Promise for Cancer Therapy
Shanmugasundaram Ganapathy-Kanniappan,Mustafa Vali,Rani Kunjithapatham,Manon Buijs,Labiq H. Syed,Pramod Rao,Shinichi Ota,Byung Kook Kwak,Romaric Loffroy,Jean Francois H. Geschwind +9 more
TL;DR: 3-bromopyruvate induces endoplasmic reticulum stress, inhibits global protein synthesis further contributing to cancer cell death, and shows tremendous potential as an anticancer agent, according to research in the laboratory.
Journal Article
Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Is Pyruvylated during 3-Bromopyruvate Mediated Cancer Cell Death
Shanmugasundaram Ganapathy-Kanniappan,Jean Francois H. Geschwind,Rani Kunjithapatham,Manon Buijs,Josephina A. Vossen,Irina Tchernyshyov,Robert N. Cole,Labiq H. Syed,Pramod Rao,Shinichi Ota,Mustafa Vali +10 more
TL;DR: GAPDH pyruvylation by 3BrPA affects its enzymatic function and is the primary intracellular target in 2D gel electrophoretic autoradiography, mass spectrometry and immunoprecipitation.