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Shannon Bevans-Fonti
Researcher at Johns Hopkins University School of Medicine
Publications - 33
Citations - 1543
Shannon Bevans-Fonti is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Intermittent hypoxia & Hypoxia (medical). The author has an hindex of 19, co-authored 30 publications receiving 1332 citations. Previous affiliations of Shannon Bevans-Fonti include Johns Hopkins University.
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Journal ArticleDOI
Intermittent hypoxia exacerbates metabolic effects of diet-induced obesity.
Luciano F. Drager,Jianguo Li,Christian Reinke,Shannon Bevans-Fonti,Jonathan C. Jun,Vsevolod Y. Polotsky +5 more
TL;DR: In conclusion, CIH exacerbates IR and induces steatohepatitis in DIO mice, suggesting that CIH may account for metabolic dysfunction in obesity.
Journal ArticleDOI
Effects of different acute hypoxic regimens on tissue oxygen profiles and metabolic outcomes
TL;DR: IH60 led to oxygen fluctuations in liver and muscle and steady hypoxia in fat and inflammation was increased only by IH60 in lean mice, which was not augmented by acute hypoxic regimens.
Journal ArticleDOI
Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4.
Luciano F. Drager,Qiaoling Yao,Karen L. Hernandez,Karen L. Hernandez,Mi Kyung Shin,Shannon Bevans-Fonti,Thomas E. Sussan,Jonathan C. Jun,Allen C. Myers,Gunilla Olivecrona,Alan R. Schwartz,Nils Halberg,Philipp E. Scherer,Gregg L. Semenza,David R. Powell,Vsevolod Y. Polotsky +15 more
TL;DR: HIF-1-mediated increase in adipose Angptl4 and the ensuing lipoprotein lipase inactivation may contribute to atherosclerosis in patients with sleep apnea.
Journal ArticleDOI
Effect of intermittent hypoxia on atherosclerosis in apolipoprotein E-deficient mice.
Jonathan C. Jun,Christian Reinke,Christian Reinke,Djahida Bedja,Dan E. Berkowitz,Shannon Bevans-Fonti,Jianguo Li,Lili A. Barouch,Kathleen L. Gabrielson,Vsevolod Y. Polotsky +9 more
TL;DR: IH accelerates atherosclerotic plaque growth in ApoE(-/-) mice without affecting plaque composition, and the mechanisms may include non-additive increases in serum lipids, and cumulative increases in blood pressure.
Journal ArticleDOI
Intermittent hypoxia inhibits clearance of triglyceride-rich lipoproteins and inactivates adipose lipoprotein lipase in a mouse model of sleep apnoea.
Luciano F. Drager,Jianguo Li,Mi Kyung Shin,Christian Reinke,Christian Reinke,Neil R. Aggarwal,Jonathan C. Jun,Shannon Bevans-Fonti,Carole Sztalryd,Sheila M. O'Byrne,Olessia Kroupa,Gunilla Olivecrona,William S. Blaner,Vsevolod Y. Polotsky +13 more
TL;DR: CIH decreases TRLP clearance and inhibits LpL activity in adipose tissue, which may contribute to atherogenesis observed in OSA, and this study examined whether chronic intermittent hypoxia can lead to hyperlipidaemia by inhibiting clearance of triglyceride rich lipoproteins.