S
Shannon Coy
Researcher at Brigham and Women's Hospital
Publications - 42
Citations - 1500
Shannon Coy is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Medicine & Cohort study. The author has an hindex of 12, co-authored 34 publications receiving 486 citations. Previous affiliations of Shannon Coy include Washington University in St. Louis & Dartmouth–Hitchcock Medical Center.
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Journal ArticleDOI
Copper induces cell death by targeting lipoylated TCA cycle proteins
Peter Tsvetkov,Shannon Coy,Boryana Petrova,Margaret Dreishpoon,A. Verma,Mai Abdusamad,Jordan Rossen,Lena M. Joesch-Cohen,Ranad Humeidi,Ryan Spangler,John K. Eaton,Evgeni M. Frenkel,Mustafa Koçak,Steven M. Corsello,Svetlana Lutsenko,Naama Kanarek,Sandro Santagata,Todd R. Golub +17 more
TL;DR: It is shown in human cells that copper-dependent, regulated cell death is distinct from known death mechanisms and is dependent on mitochondrial respiration, and that excess copper promotes the aggregation of lipoylated proteins and links mitochondrial metabolism to copper- dependent death.
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An update on the CNS manifestations of neurofibromatosis type 2
Shannon Coy,Shannon Coy,Shannon Coy,Rumana Rashid,Rumana Rashid,Anat Stemmer-Rachamimov,Sandro Santagata +6 more
TL;DR: The clinicopathologic features ofNF2, current understanding of the molecular biology of NF2, particularly with regard to central nervous system lesions, ongoing therapeutic studies, and avenues for further research are reviewed.
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Human cardiomyopathy mutations induce myocyte hyperplasia and activate hypertrophic pathways during cardiogenesis in zebrafish
Jason R Becker,Jason R Becker,Rahul C. Deo,Andreas A. Werdich,Daniela Panáková,Daniela Panáková,Shannon Coy,Calum A. MacRae,Calum A. MacRae +8 more
TL;DR: The re-creation of a human disease-causing TNNT2 splice variant demonstrates that sarcomeric mutations can alter cardiomyocyte biology at the earliest stages of heart development with distinct effects from those observed in adult hearts despite shared transcriptional responses.
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In vivo natriuretic peptide reporter assay identifies chemical modifiers of hypertrophic cardiomyopathy signalling
Jason R Becker,Tamara Y. Robinson,Chetana Sachidanandan,Amy E. Kelly,Shannon Coy,Randall T. Peterson,Calum A. MacRae +6 more
TL;DR: A luciferase-based transgenic reporter line is created that accurately modelled the pathological induction patterns of the zebrafish nppb gene and will offer a unique approach to the identification of novel chemical or genetic regulators of myocardial hypertrophy and heart failure.
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Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development
Jason R Becker,Sneha Chatterjee,Tamara Y. Robinson,Jeffrey S. Bennett,Daniela Panáková,Cristi L. Galindo,Lin Zhong,Jordan T. Shin,Shannon Coy,Amy E. Kelly,Dan M. Roden,Chee Chew Lim,Calum A. MacRae +12 more
TL;DR: The cardiac natriuretic peptides are linked in a complex hierarchy modulating cardiomyocyte numbers during development through opposing effects on carduomyocyte proliferation mediated through distinct cyclic nucleotide signaling pathways.