Mai Abdusamad

TL;DR: It is shown in human cells that copper-dependent, regulated cell death is distinct from known death mechanisms and is dependent on mitochondrial respiration, and that excess copper promotes the aggregation of lipoylated proteins and links mitochondrial metabolism to copper- dependent death.

TL;DR: Genetic and transcriptional consequences of Cas9 expression induces DNA damage and activates the p53 pathway, and it can lead to the selection of cells with p53-inactivating mutations, and Cas9 is less active in wild-type TP53 cell lines than in TP53- mutant cell lines.

TL;DR: In this paper, aneuploid cancer cells exhibited aberrant spindle geometry and dynamics, and kept dividing when the SAC was inhibited, resulting in the accumulation of mitotic defects, and in unstable and less-fit karyotypes.

TL;DR: A compendium of synthetic lethal vulnerabilities is described and V PS4A and VPS4B are nominated as high-priority therapeutic targets for cancers with 18q or 16q loss.

TL;DR: All data point to the XPR1:KIDINS220 complex - and phosphate dysregulation more broadly - as a therapeutic vulnerability in ovarian cancer.