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Shannon L. Risacher
Researcher at Indiana University
Publications - 288
Citations - 12478
Shannon L. Risacher is an academic researcher from Indiana University. The author has contributed to research in topics: Cognition & Medicine. The author has an hindex of 51, co-authored 246 publications receiving 9808 citations. Previous affiliations of Shannon L. Risacher include Indiana University – Purdue University Indianapolis & University of Texas at Arlington.
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Book ChapterDOI
Transcriptome-Guided Imaging Genetic Analysis via a Novel Sparse CCA Algorithm.
Kefei Liu,Xiaohui Yao,Jingwen Yan,Danai Chasioti,Shannon L. Risacher,Kwangsik Nho,Andrew J. Saykin,Li Shen +7 more
TL;DR: The results on real data show that using the gene expression data to guide the feature selection facilities the detection of genetic markers that are not only associated with the identified QTs, but also highly expressed there.
Journal ArticleDOI
Temporal stability of the ventral attention network and general cognition along the Alzheimer's disease spectrum.
Evgeny J. Chumin,Shannon L. Risacher,John D. West,Liana G. Apostolova,Martin R. Farlow,Brenna C. McDonald,Yu-Chien Wu,Andrew J. Saykin,Olaf Sporns +8 more
TL;DR: In this article, the modular structure of static (sFC) and time-varying (tvFC) connectivity along the AD spectrum was investigated in a two-sample Discovery/Validation design (n = 80 and 81, respectively).
Journal ArticleDOI
Differential trajectories of hypometabolism across cognitively-defined Alzheimer's disease subgroups.
Colin Groot,Shannon L. Risacher,J Q Alida Chen,Ellen Dicks,Andrew J. Saykin,Christine L. Mac Donald,Jesse Mez,Emily H. Trittschuh,Shubhabrata Mukherjee,Frederik Barkhof,Philip Scheltens,Wiesje M. van der Flier,Rik Ossenkoppele,Paul K. Crane,Alzheimer’s Disease Neuroimaging Initiative +14 more
TL;DR: In this paper, the authors employed longitudinal FDG-PET standardized uptake value ratios (SUVRs) to map hypometabolism across cognitively-defined AD subgroups and found that cognitively defined subgroups are biologically distinct.
Journal ArticleDOI
Mapre2 as a novel Alzheimer's disease target gene from gwas of CSF amyloid beta 1-42, tau and hyperphosphorylated tau in the ADNI cohort
Sungeun Kim,Kwangsik Nho,Shannon L. Risacher,Li Shen,Leslie M. Shaw,John Q. Trojanowski,Michael W. Weiner,Andrew J. Saykin +7 more
TL;DR: There is some evidence for the role of a family history, or related genetic associations, in predicting decline in cognition related to Alzheimer’s disease, and growing evidence in the literature that there is something other than APOE that is possibly determining risk and progression in subjects with aFamily history of AD.
Journal ArticleDOI
Relationship of microglial activation measured by [11C]PBR28 PET, atrophy on MRI and plasma biomarkers in individuals with and at risk for Alzheimer's disease
Shannon L. Risacher,Sungeun Kim,Karmen K. Yoder,Li Shen,John D. West,Brenna C. McDonald,Yang Wang,Kwangsik Nho,Eileen F. Tallman,Gary D. Hutchins,James W. Fletcher,Bernardino Ghetti,Sujuan Gao,Martin R. Farlow,Andrew J. Saykin +14 more
TL;DR: Score Name Description T-MSBL-FP Mixed L2/L1 RIDGE ADAS ADAS total score 0.683 6 0.663 6 0068 0.681 6 1.037 0.042 RAVLT-Total Total score of the first 5 trials 0.592 60.561 7 0.054 0.057 RAV LT-T30 30 minute delay # of words recalled 0.534 6 2 0.073 0.