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Shannon L. Risacher
Researcher at Indiana University
Publications - 288
Citations - 12478
Shannon L. Risacher is an academic researcher from Indiana University. The author has contributed to research in topics: Cognition & Medicine. The author has an hindex of 51, co-authored 246 publications receiving 9808 citations. Previous affiliations of Shannon L. Risacher include Indiana University – Purdue University Indianapolis & University of Texas at Arlington.
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Journal ArticleDOI
Genomic copy number analysis in Alzheimer's disease and mild cognitive impairment: An ADNI study
Shanker Swaminathan,Sungeun Kim,Li Shen,Shannon L. Risacher,Tatiana Foroud,Nathan Pankratz,Steven G. Potkin,Matthew J. Huentelman,David Craig,Michael W. Weiner,Michael W. Weiner,Andrew J. Saykin +11 more
TL;DR: Although no excess CNV burden was observed in cases (AD and/or MCI) relative to controls (HC), gene-based analyses revealed CNVs overlapping the candidate gene CHRFAM7A, as well as CSMD1, SLC35F2, HNRNPCL1, NRXN1, and ERBB4 regions, only in cases.
Book ChapterDOI
Identifying neuroimaging and proteomic biomarkers for MCI and AD via the elastic net
Li Shen,Sungeun Kim,Yuan Qi,Mark Inlow,Shanker Swaminathan,Kwangsik Nho,Jing Wan,Shannon L. Risacher,Leslie M. Shaw,John Q. Trojanowski,Michael W. Weiner,Andrew J. Saykin +11 more
TL;DR: This study focuses on integrative analysis of structural MRI data and proteomic data from an RBM panel to examine their predictive power and identify relevant biomarkers in a large MCI/AD cohort.
Journal ArticleDOI
Protective variant for hippocampal atrophy identified by whole exome sequencing.
Kwangsik Nho,Sungeun Kim,Shannon L. Risacher,Li Shen,Jason J. Corneveaux,Shanker Swaminathan,Hai Lin,Vijay K. Ramanan,Yunlong Liu,Tatiana Foroud,Mark Inlow,Ashley L. Siniard,Rebecca Reiman,Paul S. Aisen,Ronald C. Petersen,Robert C. Green,Clifford R. Jack,Michael W. Weiner,Michael W. Weiner,Clinton T. Baldwin,Kathryn L. Lunetta,Lindsay A. Farrer,Simon J. Furney,Simon J. Furney,Simon Lovestone,Simon Lovestone,Andrew Simmons,Andrew Simmons,Patrizia Mecocci,Bruno Vellas,Magda Tsolaki,Iwona Kłoszewska,Hilkka Soininen,Brenna C. McDonald,Martin R. Farlow,Bernardino Ghetti,Matthew J. Huentelman,Andrew J. Saykin +37 more
TL;DR: REST is a master regulator of neurogenesis and neuronal differentiation that has not been previously implicated in Alzheimer's disease and its functional pathways are nominated as protective and illustrate the potential of combining next‐generation sequencing with neuroimaging to discover novel disease mechanisms and potential therapeutic targets.
Journal ArticleDOI
Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort.
Shanker Swaminathan,Li Shen,Shannon L. Risacher,Karmen K. Yoder,John D. West,Sungeun Kim,Kwangsik Nho,Kwangsik Nho,Tatiana Foroud,Mark Inlow,Mark Inlow,Steven G. Potkin,Matthew J. Huentelman,David Craig,William J. Jagust,William J. Jagust,Robert A. Koeppe,Chester A. Mathis,Clifford R. Jack,Michael W. Weiner,Michael W. Weiner,Andrew J. Saykin +21 more
TL;DR: A gene-based association analysis of 15 quality-controlled amyloid-pathway associated candidate genes in 103 Alzheimer’s Disease Neuroimaging Initiative participants indicated that non-carriers of the minor allele had higher PiB uptake in frontal regions compared to carriers.
Journal ArticleDOI
Relationship between baseline brain metabolism measured using [18F]FDG PET and memory and executive function in prodromal and early Alzheimer’s disease
Christian G. Habeck,Shannon L. Risacher,Grace J. Lee,M. Maria Glymour,Elizabeth C. Mormino,Shubhabrata Mukherjee,Sungeun Kim,Kwangsik Nho,Charles DeCarli,Andrew J. Saykin,Paul K. Crane +10 more
TL;DR: The associations between brain metabolism and cognition in this study suggest the importance of parietal and temporal lobar regions in memory and executive function in the early stages of disease and an increased importance of frontal regions for memory with increasing impairment.