Shannon L. Risacher

TL;DR: Abnormal gene expression patterns may contribute to the onset and progression of late‐onset Alzheimer's disease (LOAD) and may be a cause for concern.

TL;DR: This chapter explores neuroimaging measures, including structural and functional measures from magnetic resonance imaging (MRI) and molecular measures primarily from positron emission tomography (PET), in healthy aging adults and in a number of neurologic diseases.

TL;DR: The association between age at injury (AAI) and long‐term cognitive outcome of traumatic brain injuries (TBI) is debatable.

TL;DR: Lower levels of alanine aminotransferase were associated with increased amyloid-β deposition, reduced brain glucose metabolism, greater brain atrophy, diagnosis of Alzheimer disease, and poor cognition, meaning consistent associations of serum-based liver function markers with Alzheimer disease biomarkers highlight the involvement of metabolic disturbances in the pathophysiology of Alzheimer Disease.

TL;DR: Wang et al. as discussed by the authors developed a graph-based deep neural network to simultaneously model brain structure and function in Mild Cognitive Impairment (MCI): the topology of the graph is initialized using structural network (from diffusion MRI) and iteratively updated by incorporating functional information (from functional MRI) to maximize the capability of differentiating MCI patients from elderly normal controls.