Shasha Chong

TL;DR: Live-cell single-molecule imaging revealed that TF LCDs interact to form local high-concentration hubs at both synthetic DNA arrays and endogenous genomic loci, suggesting that under physiological conditions, rapid, reversible, and selective multivalent LCD-LCD interactions occur between TFs and the RNA Pol II machinery to activate transcription.

TL;DR: There has been a tremendous explosion in the number of papers written within the first weeks of the COVID-19 pandemic evaluating potential advances, comparable reagents, and alternatives to the "gold-standard" CDC RT-PCR test, including both peer-reviewed and preprint articles.

TL;DR: It is shown that positive supercoiling buildup on a DNA segment by transcription slows down transcription elongation and eventually stops transcription initiation, and proves that transcriptional bursting of highly expressed genes in bacteria is primarily caused by reversible gyrase dissociation from and rebinding to aDNA segment, changing the supercoiled level of the segment.

TL;DR: In this article, a pump-probe experiment was conducted on photoexcitation by a pump pulse, and the sample was stimulated down to the ground state by a time-delayed probe pulse, the intensity of which was concurrently increased.

TL;DR: The binding affinity of a protein near a DNA hairpin is similarly dependent on their separation, which—together with molecular dynamics simulations—suggests that deformation of the double-helical structure is the origin of DNA allostery.