S
Shay Tzur
Researcher at Rambam Health Care Campus
Publications - 50
Citations - 3418
Shay Tzur is an academic researcher from Rambam Health Care Campus. The author has contributed to research in topics: Exome sequencing & Population. The author has an hindex of 23, co-authored 49 publications receiving 3032 citations. Previous affiliations of Shay Tzur include Tel Aviv University & University of Haifa.
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Journal ArticleDOI
Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene
Shay Tzur,Saharon Rosset,Revital Shemer,Guennady Yudkovsky,Sara Selig,Ayele Tarekegn,Ayele Tarekegn,Endashaw Bekele,Neil Bradman,Walter G. Wasser,Doron M. Behar,Karl Skorecki +11 more
TL;DR: This work uses recently released sequences from the 1000 Genomes Project to identify two western African-specific missense mutations in the neighboring APOL1 gene, and demonstrates that these are more strongly associated with ESKD than previously reported MYH9 variants.
Journal ArticleDOI
The dawn of human matrilineal diversity.
Doron M. Behar,Richard Villems,Himla Soodyall,Jason Blue-Smith,Luísa Pereira,Ene Metspalu,Rosaria Scozzari,Heeran Makkan,Shay Tzur,David Comas,Jaume Bertranpetit,Lluis Quintana-Murci,Chris Tyler-Smith,R. Spencer Wells,Saharon Rosset,Saharon Rosset +15 more
TL;DR: The tree phylogeny and coalescence calculations suggest that Khoisan matrilineal ancestry diverged from the rest of the human mtDNA pool 90,000-150,000 years before present and that at least five additional, currently extant maternal lineages existed during this period in parallel.
Journal ArticleDOI
Preliminary Report: Missense mutations in the APOL gene family are associated with end stage kidney disease risk previously attributed to the MYH9 gene
Shay Tzur,Saharon Rosset,Revital Shemer,Guennady Yudkovsky,Sara Selig,Ayele Tarekegn,Endashaw Bekele,Neil Bradman,Walter G. Wasser,Doron M. Behar,Karl Skorecki +10 more
TL;DR: In this article, the authors used recently released sequences from the 1000 Genomes Project to identify two western African specific missense mutations (S342G and I384M) in the neighbouring APOL1 gene, and demonstrate that these are more strongly associated with ESKD than previously reported MYH9 variants.
Journal ArticleDOI
Maternal Traces of Deep Common Ancestry and Asymmetric Gene Flow Between Pygmy Hunter-Gatherers and Bantu-speaking Farmers
Lluis Quintana-Murci,Hélène Quach,Christine Harmant,Francesca Luca,Blandine Massonnet,Etienne Patin,Lucas Sica,Patrick Mouguiama-Daouda,David Comas,Shay Tzur,Oleg Balanovsky,Kenneth K. Kidd,Judith R. Kidd,Lolke van der Veen,Jean-Marie Hombert,Antoine Gessain,Paul Verdu,Alain Froment,Serge Bahuchet,Evelyne Heyer,Jean Dausset,Antonio Salas,Doron M. Behar +22 more
TL;DR: Analysis of mtDNA variation in 1,404 individuals from 20 farming populations and 9 Pygmy populations from Central Africa revealed that this region was colonized gradually, with an initial L1c-rich ancestral population ultimately giving rise to current-day farmers and Pygmies, in whom L1 c1a is the only surviving clade.
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The Matrilineal Ancestry of Ashkenazi Jewry: Portrait of a Recent Founder Event
Doron M. Behar,Ene Metspalu,Toomas Kivisild,Alessandro Achilli,Yarin Hadid,Shay Tzur,Luísa Pereira,António Amorim,Lluis Quintana-Murci,Kari Majamaa,Corinna Herrnstadt,Neil Howell,Oleg Balanovsky,Oleg Balanovsky,I. A. Kutuev,I. A. Kutuev,Andrey Pshenichnov,Andrey Pshenichnov,David Gurwitz,Batsheva Bonne-Tamir,Antonio Torroni,Richard Villems,Karl Skorecki +22 more
TL;DR: It is shown that close to one-half of Ashkenazi Jews can be traced back to only 4 women carrying distinct mtDNAs that are virtually absent in other populations, with the important exception of low frequencies among non-Ashkenazi Jewry.