H
Heeran Makkan
Researcher at National Health Laboratory Service
Publications - 6
Citations - 428
Heeran Makkan is an academic researcher from National Health Laboratory Service. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 2, co-authored 2 publications receiving 411 citations.
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Journal ArticleDOI
The dawn of human matrilineal diversity.
Doron M. Behar,Richard Villems,Himla Soodyall,Jason Blue-Smith,Luísa Pereira,Ene Metspalu,Rosaria Scozzari,Heeran Makkan,Shay Tzur,David Comas,Jaume Bertranpetit,Lluis Quintana-Murci,Chris Tyler-Smith,R. Spencer Wells,Saharon Rosset,Saharon Rosset +15 more
TL;DR: The tree phylogeny and coalescence calculations suggest that Khoisan matrilineal ancestry diverged from the rest of the human mtDNA pool 90,000-150,000 years before present and that at least five additional, currently extant maternal lineages existed during this period in parallel.
Journal ArticleDOI
Mitochondrial HVRI and whole mitogenome sequence variations portray similar scenarios on the genetic structure and ancestry of northeast Africans
Maha M. Osman,Hisham Y. Hassan,Mohammed A. Elnour,Heeran Makkan,Eyoab Iyasu Gebremeskel,Eyoab Iyasu Gebremeskel,Thoyba Gais,Mahmoud Koko,Himla Soodyall,Muntaser E. Ibrahim +9 more
TL;DR: The observed regional variation and diversity, depicted in various metrics imply that the female lineages in this part of Africa are likely to have been shaped by a longer history of in-situ evolution.
Journal ArticleDOI
Sequencing Mycobacteria and Algorithm-determined Resistant Tuberculosis Treatment (SMARTT): a study protocol for a phase IV pragmatic randomized controlled patient management strategy trial
Annelies Van Rie,Elise De Vos,Emilyn Costa,Lennert Verboven,Felex Ndebele,Tim H. Heupink,Steven Abrams,Noriah Maraba,Heeran Makkan,Trevor Beattie,Zandile Sibeko,S’thabiso Bohlela,Pulane Segwaba,Emmanuel Ayodeji Ogunbayo,Nomadlozi Mhlambi,Felicia Wells,Leen Rigouts,Gary Maartens,Francesca Conradie,John Black,Samantha Potgieter,Biotumelo L Fanampe,Anneke Van der Spoel Van Dyk,Salome Charalambous,Gavin J. Churchyard,Robin M. Warren +25 more
TL;DR: In this article , a randomized controlled medical device trial of a WGS-guided automated treatment recommendation strategy for individualized treatment of Rifampicin-resistant tuberculosis (RR-TB) patients is presented.
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High Levels of Pretreatment HIV-1 Drug Resistance Mutations Among South African Women Who Acquired HIV During a Prospective Study
Ivana Beesham,Urvi M. Parikh,John W. Mellors,Dvora Joseph Davey,Renee Heffron,Thesla Palanee-Phillips,Shannon Bosman,Mags Beksinska,Jennifer A. Smit,Khatija Ahmed,Heeran Makkan,Pearl Selepe,Cheryl Louw,Philip Kotze,G Justus Hofmeyr,Mandisa Singata-Madliki,Helen Rees,Jared M. Baeten,Carole L. Wallis +18 more
TL;DR: The high levels of PDR among South African women with recent HIV infection, particularly to NNRTIs, strongly support the recent change to the South African national HIV treatment guidelines to transition to a first-line drug regimen that excludes NN RTIs.
Journal ArticleDOI
High HIV incidence among young women in South Africa: Data from a large prospective study
Thesla Palanee-Phillips,Helen Rees,Kate B. Heller,Khatija Ahmed,Joanne Batting,Ivana Beesham,Renee Heffron,Jessica Justman,Heeran Makkan,Timothy D. Mastro,Susan Morrison,Nelly Mugo,Gonasagrie Nair,James Kiarie,Neena M. Philip,Melanie Pleaner,Krishnaveni Reddy,Pearl Selepe,Petrus S. Steyn,Caitlin W Scoville,Jenni Smit,Katherine K. Thomas,Deborah Donnell,Jared M. Baeten +23 more
TL;DR: HIV incidence was high among South African women seeking contraceptive services and integration of diagnostic management of sexually transmitted infections alongside delivery of HIV prevention options in health facilities providing contraception services are needed to mitigate ongoing risks of HIV acquisition.