M
Mitinori Saitou
Researcher at Kyoto University
Publications - 176
Citations - 23248
Mitinori Saitou is an academic researcher from Kyoto University. The author has contributed to research in topics: Germ cell & Embryonic stem cell. The author has an hindex of 68, co-authored 161 publications receiving 20176 citations. Previous affiliations of Mitinori Saitou include Wellcome Trust/Cancer Research UK Gurdon Institute & University College London.
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Journal ArticleDOI
Complex Phenotype of Mice Lacking Occludin, a Component of Tight Junction Strands
Mitinori Saitou,Mikio Furuse,Hiroyuki Sasaki,Jörg-Dieter Schulzke,Michael Fromm,Hiroshi Takano,Tetsuo Noda,Shoichiro Tsukita +7 more
TL;DR: The generation and analysis of mice carrying a null mutation in the occludin gene suggested that the functions of TJs as well as occlUDin are more complex than previously supposed.
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Reconstitution of the Mouse Germ Cell Specification Pathway in Culture by Pluripotent Stem Cells
TL;DR: The generation of primordial germ cell-like cells (PGCLCs) in mice with robust capacity for spermatogenesis is demonstrated and provided a paradigm for the first step of in vitro gametogenesis.
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Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins
TL;DR: Detailed analyses showed that ZO-2 andZO-3 are recruited to the claudin-based networks through PDZ1 and PDZ2 domains of Z o-1/Zo-2/Z o-3 were also recruited to claudIn-based TJs, when introduced into cultured epithelial cells.
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Blimp1 is a critical determinant of the germ cell lineage in mice
Yasuhide Ohinata,Bernhard Payer,Dónal O'Carroll,Katia Ancelin,Yukiko Ono,Mitsue Sano,Sheila C. Barton,Tetyana V. Obukhanych,Michel C. Nussenzweig,Alexander Tarakhovsky,Mitinori Saitou,M. Azim Surani +11 more
TL;DR: It is shown that Blimp1 (also known as Prdm1), a known transcriptional repressor, has a critical role in the foundation of the mouse germ cell lineage, as its disruption causes a block early in the process of primordial germ cell formation.
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A molecular programme for the specification of germ cell fate in mice
TL;DR: It is shown that fragilis, an interferon-inducible transmembrane protein, marks the onset of germ cell competence, and it is proposed that through homotypic association, it demarcates germ cells from somatic neighbours.