Shigeki Ohta

TL;DR: Aged mice exhibited no differences from young adult mice in their ability to discriminate between two discrete odors but were significantly poorer at performing discriminations between similar odors, suggesting that the impairment in fine olfactory discrimination with age may result from a reduction in EGF-dependent Olfactory neurogenesis.

TL;DR: The results suggest that adrenomedullin elicits the hypotensive effect through at least two mechanisms, a direct action on vascular smooth muscle cells to increase intracellular cAMP and an action on endothelial cells to stimulate nitric oxide release, with both leading to vascular relaxation.

TL;DR: This in vitro differentiation system should prove useful for understanding human melanocyte biology and revealing the mechanism of various pigment cell disorders, including melanoma.

TL;DR: Results indicate that downregulation of KIF23 decreases proliferation of glioma cells and that Kif23 may be a novel therapeutic target in malignant gliomas.

TL;DR: Macrophage migration inhibitory factor (MIF) can induce NSPC proliferation and maintenance by multiple signaling pathways acting synergistically, and it may be a potential therapeutic factor, capable of activating NSPCs, for the treatment of degenerative brain disorders.