Shigeru Hirota

TL;DR: The results indicate that FAS gene is up-regulated by hypoxia via activation of the Akt and HIF1 followed by the induction of the SREBP-1 gene, and that Hypoxia-induced chemoresistance is partly due to the up-regulation of FAS.

TL;DR: BMP7 released by bone marrow stromal cells induces reversible senescence of prostate cancer stem-like cells, and BMPR2 expression inversely correlates with bone metastasis and recurrence in prostate cancer patients.

TL;DR: It is strongly suggested that Drg-1 is a candidate metastasis suppressor gene for prostate cancer and may serve as a useful prognostic marker.

TL;DR: It is found that CSCs isolated from metastatic breast cell lines are significantly more metastatic than non-CSC populations in an organ-specific manner and in vitro experiments indicate that miR-7 attenuates the abilities of invasion and self-renewal of C SCs by modulating KLF4 expression.

TL;DR: Direct evidence is provided that DARC is essential for the function of CD82 as a suppressor of metastasis, and that this interaction leads to inhibition of tumor cell proliferation and induction of senescence by modulating the expression of TBX2 and p21.