S
Shih-Jen Tsai
Researcher at Taipei Veterans General Hospital
Publications - 660
Citations - 16540
Shih-Jen Tsai is an academic researcher from Taipei Veterans General Hospital. The author has contributed to research in topics: Medicine & Population. The author has an hindex of 57, co-authored 571 publications receiving 13687 citations. Previous affiliations of Shih-Jen Tsai include National Yang-Ming University & Wyss Institute for Biologically Inspired Engineering.
Papers
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Journal ArticleDOI
The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression
Jen-Ping Hwang,Jen-Ping Hwang,Shih-Jen Tsai,Shih-Jen Tsai,Chen-Jee Hong,Chen-Jee Hong,Chen-Hong Yang,Chen-Hong Yang,Jiing-Feng Lirng,Jiing-Feng Lirng,Ya-Min Yang +10 more
TL;DR: The results suggest that the BDNF Val66Met polymorphism is a relevant risk factor for geriatric depression.
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Association study of the serotonin transporter promoter polymorphism and symptomatology and antidepressant response in major depressive disorders.
TL;DR: Patients with the l/l genotype had a significantly better response to SSRI (fluoxetine) when compared with s allele carriers, as evaluated on the basis of total and cluster depressive symptoms and Hamilton Depression Rating Scale-score percentage change.
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Association study of a brain-derived neurotrophic-factor genetic polymorphism and major depressive disorders, symptomatology, and antidepressant response.
TL;DR: A trend to improved 4‐week‐fluoxetine antidepressant response was demonstrated for heterozygous patients in comparison to homozygous analogs, suggesting the BDNF polymorphism investigated plays no major role in the pathogenesis of MDD.
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Association study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders, age of onset and suicidal behavior.
TL;DR: It seems reasonable to suggest that the positive association between BDNF gene Val66Met polymorphism and bipolar disorder has only been demonstrated for a Caucasian population but not for a Japanese analog or the authors' Chinese sample, and that this association is ethnicity dependent.
Journal ArticleDOI
Medial reward and lateral non-reward orbitofrontal cortex circuits change in opposite directions in depression
Wei Cheng,Edmund T. Rolls,Jiang Qiu,Jiang Qiu,Wei Liu,Wei Liu,Yanqing Tang,Chu Chung Huang,Xin Fa Wang,Jie Zhang,Wei Lin,Li-Rong Zheng,Li-Rong Zheng,Jun Cai Pu,Shih-Jen Tsai,Albert C. Yang,Albert C. Yang,Ching Po Lin,Fei Wang,Peng Xie,Jianfeng Feng +20 more
TL;DR: The first brain-wide voxel-level resting state functional connectivity neuroimaging analysis of depression is reported, and it is shown that the functional connectivity of the lateral orbitofrontal cortex Brodmann area 47/12 with these three brain areas was lower in the medicated than the unmedicated patients, consistent with the hypothesis that the increased functional connectivity is related to depression.