S
Shiki Takamura
Researcher at Kindai University
Publications - 47
Citations - 2307
Shiki Takamura is an academic researcher from Kindai University. The author has contributed to research in topics: Cytotoxic T cell & CD8. The author has an hindex of 23, co-authored 41 publications receiving 1902 citations. Previous affiliations of Shiki Takamura include Rakuno Gakuen University & Trudeau Institute.
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Journal ArticleDOI
Activation phenotype, rather than central- or effector-memory phenotype, predicts the recall efficacy of memory CD8+ T cells.
Hirokazu Hikono,Jacob E. Kohlmeier,Shiki Takamura,Susan T. Wittmer,Alan D. Roberts,David L. Woodland +5 more
TL;DR: It is demonstrated that activation markers, such as CD27 and CD43, define three distinct subpopulations of memory CD8+ T cells that differ in their capacities to mount recall responses, and suggested that activation and migration markers define distinct, and unrelated, characteristics of memory T cells.
Journal ArticleDOI
CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways
Alexander N. Wein,Sean R. McMaster,Shiki Takamura,Paul Dunbar,Emily K. Cartwright,Sarah L. Hayward,Daniel T. McManus,Takeshi Shimaoka,Satoshi Ueha,Tatsuya Tsukui,Tomoko Masumoto,Makoto Kurachi,Kouji Matsushima,Jacob E. Kohlmeier +13 more
TL;DR: This work shows that the CXCR6/CXCL16 axis governs the partitioning of TRM cells to different compartments of the lung and maintains the airway TRM cell pool.
Journal ArticleDOI
Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance.
Shiki Takamura,Hideki Yagi,Yoshiyuki Hakata,Chihiro Motozono,Sean R. McMaster,Tomoko Masumoto,Makoto Fujisawa,Tomomi Chikaishi,Junko Komeda,Jun Itoh,Miki Umemura,Ami Kyusai,Michio Tomura,Toshinori Nakayama,David L. Woodland,Jacob E. Kohlmeier,Masaaki Miyazawa +16 more
TL;DR: It is shown that most lung CD8+ TRM cells are not maintained in the inducible bronchus-associated lymphoid tissue (iBALT) but are maintained in specific niches created at the site of tissue regeneration, which are termed as repair-associated memory depots (RAMDs).
Journal ArticleDOI
Chemokine receptor CXCR3 facilitates CD8+ T cell differentiation into short-lived effector cells leading to memory degeneration
Makoto Kurachi,Junko Kurachi,Fumiko Suenaga,Tatsuya Tsukui,Jun Abe,Satoshi Ueha,Michio Tomura,Kei Sugihara,Shiki Takamura,Kazuhiro Kakimi,Kouji Matsushima +10 more
TL;DR: CXCR3 regulates CD8+ T cell recruitment to sites of inflammation, thus dictating CD8- T cell contraction and subsequent effector/memory cell fate.
Journal ArticleDOI
Premature Terminal Exhaustion of Friend Virus-Specific Effector CD8+ T Cells by Rapid Induction of Multiple Inhibitory Receptors
Shiki Takamura,Sachiyo Tsuji-Kawahara,Hideo Yagita,Hisaya Akiba,Mayumi Sakamoto,Tomomi Chikaishi,Maiko Kato,Masaaki Miyazawa +7 more
TL;DR: Combined blockade of PD-1 and Tim-3 during the priming/differentiation phase rescued FV-specific CD8+ T cells from becoming terminally exhausted, resulting in improved CD8- T cell functionality and virus control.