M
Makoto Kurachi
Researcher at Kanazawa University
Publications - 52
Citations - 8426
Makoto Kurachi is an academic researcher from Kanazawa University. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 27, co-authored 48 publications receiving 5981 citations. Previous affiliations of Makoto Kurachi include University of Pennsylvania & University of Tokyo.
Papers
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Journal ArticleDOI
Molecular and cellular insights into T cell exhaustion
E. John Wherry,Makoto Kurachi +1 more
TL;DR: Recent advances that provide a clearer molecular understanding of T cell exhaustion are reviewed and reveal new therapeutic targets for persisting infections and cancer.
Journal ArticleDOI
Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
Kristen E. Pauken,Morgan A. Sammons,Pamela M. Odorizzi,Sasikanth Manne,Jernej Godec,Omar Khan,Adam M. Drake,Zeyu Chen,Debattama R. Sen,Makoto Kurachi,R. Anthony Barnitz,Caroline Bartman,Bertram Bengsch,Alexander C. Huang,Jason M. Schenkel,Golnaz Vahedi,W. Nicholas Haining,W. Nicholas Haining,Shelley L. Berger,E. John Wherry +19 more
TL;DR: The data indicate that epigenetic fate inflexibility may limit current immunotherapies, and PD-1 pathway blockade resulted in transcriptional rewiring and reengagement of effector circuitry in the TEX epigenetic landscape.
Journal ArticleDOI
The epigenetic landscape of T cell exhaustion
Debattama R. Sen,James Kaminski,R. Anthony Barnitz,Makoto Kurachi,Ulrike Gerdemann,Kathleen B. Yates,Hsiao-Wei Tsao,Jernej Godec,Martin W. LaFleur,Flavian D. Brown,Pierre Tonnerre,Raymond T. Chung,Damien C. Tully,Todd M. Allen,Nicole Frahm,Georg M. Lauer,E. John Wherry,Nir Yosef,Nir Yosef,W. Nicholas Haining,W. Nicholas Haining,W. Nicholas Haining +21 more
TL;DR: The accessible chromatin landscape in exhausted CD8+ T cells is defined and shown that it is distinct from functional memory CD8 + T cells, suggesting that exhausted T cells are a distinct lineage.
Journal ArticleDOI
Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8+ T Cell Exhaustion
Bertram Bengsch,Andy L. Johnson,Makoto Kurachi,Pamela M. Odorizzi,Kristen E. Pauken,John Attanasio,Erietta Stelekati,Laura M. McLane,Michael A. Paley,Greg M. Delgoffe,E. John Wherry +10 more
TL;DR: A key metabolic control event early in exhaustion is highlighted and it is suggested that manipulating glycolytic and mitochondrial metabolism might enhance checkpoint blockade outcomes.
Journal ArticleDOI
Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms
Jean-Christophe Beltra,Sasikanth Manne,Mohamed S. Abdel-Hakeem,Makoto Kurachi,Josephine R. Giles,Zeyu Chen,Valentina Casella,Shin Foong Ngiow,Omar Khan,Yinghui Jane Huang,Patrick Yan,Kito Nzingha,Wei Xu,Ravi K. Amaravadi,Xiaowei Xu,Giorgos C. Karakousis,Tara C. Mitchell,Lynn M. Schuchter,Alexander C. Huang,E. John Wherry +19 more
TL;DR: A four-cell-stage developmental framework for Tex cells is defined and the control mechanisms underlying subset transitions are identified and a key interplay between TCF1, T-bet, and Tox is defined in the process.