H
Huikun Wang
Researcher at National Institute on Drug Abuse
Publications - 15
Citations - 1548
Huikun Wang is an academic researcher from National Institute on Drug Abuse. The author has contributed to research in topics: Ventral tegmental area & Dopamine. The author has an hindex of 10, co-authored 11 publications receiving 1364 citations. Previous affiliations of Huikun Wang include Chinese Academy of Sciences & United States Department of Health and Human Services.
Papers
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Journal ArticleDOI
ATP Released by Astrocytes Mediates Glutamatergic Activity-Dependent Heterosynaptic Suppression
Jing Ming Zhang,Huikun Wang,Chang Quan Ye,Woo Ping Ge,Yiren Chen,Zheng Lin Jiang,Chien Ping Wu,Mu-ming Poo,Mu-ming Poo,Shumin Duan +9 more
TL;DR: It is reported that ATP released from astrocytes as a result of neuronal activity can also modulate central synaptic transmission, and neuron-glia crosstalk may participate in activity-dependent synaptic modulation.
Journal ArticleDOI
Long-term potentiation of neuron-glia synapses mediated by Ca2+-permeable AMPA receptors.
TL;DR: It is reported that these neuron-glia synapses undergo activity-dependent modifications analogous to long-term potentiation (LTP) at excitatory synapses, a hallmark of neuronal plasticity.
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Cocaine Drives Aversive Conditioning via Delayed Activation of Dopamine-Responsive Habenular and Midbrain Pathways
Thomas C. Jhou,Cameron H. Good,Courtney S. Rowley,Sheng-ping Xu,Huikun Wang,Nathan W. Burnham,Alexander F. Hoffman,Carl R. Lupica,Satoshi Ikemoto +8 more
TL;DR: Electrophysiological recordings in awake rats indicate that LHb/RMTg pathways contribute critically to cocaine-induced avoidance behaviors, while also participating in reciprocally inhibitory interactions with dopamine neurons.
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A glutamatergic reward input from the dorsal raphe to ventral tegmental area dopamine neurons.
Jia Qi,Shiliang Zhang,Hui-Ling Wang,Huikun Wang,Jose de Jesus Aceves Buendia,Alexander F. Hoffman,Carl R. Lupica,Rebecca P. Seal,Marisela Morales +8 more
TL;DR: Findings indicate that the DR-VGluT3 pathway to VTA utilizes glutamate as a neurotransmitter and is a substrate linking the DR—one of the most sensitive reward sites in the brain—to VTA dopaminergic neurons.
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Dorsal Raphe Dual Serotonin-Glutamate Neurons Drive Reward by Establishing Excitatory Synapses on VTA Mesoaccumbens Dopamine Neurons.
Hui Ling Wang,Shiliang Zhang,Jia Qi,Huikun Wang,Roger Cachope,Carlos A. Mejias-Aponte,Jorge A. Gomez,Gabriel E Mateo-Semidey,Gerard M.J. Beaudoin,Carlos A. Paladini,Joseph F. Cheer,Marisela Morales +11 more
TL;DR: A path-specific input from DR serotonergic neurons to VTA that promotes reward by the release of glutamate and activation of mesoaccumbens dopamine neurons is suggested.