Shin Sato

TL;DR: Several candidate compounds to inhibit LSD1 are designed and synthesized, based on the structures of LSD1 and monoamine oxidase B (MAO-B), in complex with an antidepressant tranylcypromine (2-PCPA) derivative, potential pharmaceutical candidates for cancer or latent virus infection.

TL;DR: The crystal structure of the cross-linked complex of the liver oncoprotein gankyrin and the C-terminal domain of S6 proteasomal protein (S6C) was determined, showing the high selectivity of formation of cross-links by pBpa and exhibiting little structural distortion from the native complex structure.

TL;DR: Spiroindoline derivative 40c (RK-287107) was discovered as a potent TNKS/TNKS2 inhibitor with >7000-fold selectivity against the PARP1 enzyme, which inhibits WNT-responsive TCF reporter activity and proliferation of human colorectal cancer cell line COLO-320DM.

TL;DR: It is reported that the LRR domain of ANP32B possesses histone chaperone activity and forms a curved structure with a parallel beta-sheet on the concave side and mostly helical elements on the convex side, which provides a structural framework for understanding the functional mechanisms of acidic hist one chaperones.

TL;DR: This method enables the installation of authentic Nε‐monomethyllysines at multiple positions within a protein for large‐scale production.