T
Teruki Honma
Researcher at Tokyo Institute of Technology
Publications - 99
Citations - 2459
Teruki Honma is an academic researcher from Tokyo Institute of Technology. The author has contributed to research in topics: Fragment molecular orbital & Medicine. The author has an hindex of 20, co-authored 81 publications receiving 1819 citations. Previous affiliations of Teruki Honma include University of Tokyo & Hokkaido University.
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Journal ArticleDOI
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity
Miki Okada-Iwabu,Toshimasa Yamauchi,Masato Iwabu,Teruki Honma,Ken-ichi Hamagami,Koichi Matsuda,Mamiko Yamaguchi,Hiroaki Tanabe,Tomomi Kimura-Someya,Mikako Shirouzu,Hitomi Ogata,Kumpei Tokuyama,Kohjiro Ueki,Tetsuo Nagano,Akiko Tanaka,Shigeyuki Yokoyama,Takashi Kadowaki +16 more
TL;DR: AdipoRon showed very similar effects to adiponectin in muscle and liver, such as activation of AMPK and PPAR-α pathways, and ameliorated insulin resistance and glucose intolerance in mice fed a high-fat diet, and is a promising therapeutic approach for the treatment of obesity-related diseases such as type 2 diabetes.
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Structure of the trypanosome cyanide-insensitive alternative oxidase
Tomoo Shiba,Yasutoshi Kido,Kimitoshi Sakamoto,Daniel Ken Inaoka,Chiaki Tsuge,Ryoko Tatsumi,Gen Takahashi,Emmanuel Oluwadare Balogun,Emmanuel Oluwadare Balogun,Takeshi Nara,Takashi Aoki,Teruki Honma,Akiko Tanaka,Masayuki Inoue,Shigeru Matsuoka,Hiroyuki Saimoto,Anthony L. Moore,Shigeharu Harada,Kiyoshi Kita +18 more
TL;DR: Crystal structures of the trypanosomal alternative oxidase in the absence and presence of ascofuranone derivatives reveal that the oxidase is a homodimer with the nonhaem diiron carboxylate active site buried within a four-helix bundle.
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The Translation Inhibitor Rocaglamide Targets a Bimolecular Cavity between eIF4A and Polypurine RNA.
Shintaro Iwasaki,Shintaro Iwasaki,Wakana Iwasaki,Mari Takahashi,Ayako Sakamoto,Chiduru Watanabe,Yuichi Shichino,Stephen N. Floor,Koichi Fujiwara,Mari Mito,Kosuke Dodo,Mikiko Sodeoka,Hiroaki Imataka,Teruki Honma,Kaori Fukuzawa,Takuhiro Ito,Nicholas T. Ingolia +16 more
TL;DR: An RNA-sequence-selective interfacial inhibitor fitting into the space shaped cooperatively by protein and RNA with specific sequences is provided, providing an example of an RNA- sequence-selectives interfacial inhibition.
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Combining Machine Learning and Pharmacophore-Based Interaction Fingerprint for in Silico Screening
TL;DR: A new pharmacophore-based interaction fingerprint is developed and its usefulness for in silico screening is examined using machine learning techniques such as support vector machine (SVM) and random forest (RF) instead of similarity-based ranking.
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Predicting human liver microsomal stability with machine learning techniques.
Yojiro Sakiyama,Hitomi Yuki,Takashi Moriya,Kazunari Hattori,Misaki Suzuki,Kaoru Shimada,Teruki Honma +6 more
TL;DR: The results suggest that nonlinear/ensemble-based classification methods might prove useful in the area of in silico ADME modeling.