Shin Takagi

TL;DR: Fractalkine and CX3CR1 represent new types of leukocyte trafficking regulators, performing both adhesive and chemotactic functions.

TL;DR: It is demonstrated that the T cell-directed CC chemokine thymus and activation-regulated Chemokine (TARC) was abundantly produced by monocytes treated with granulocyte macrophage colony stimulating factor (GM-CSF) or IL-3, especially in the presence of IL-4 and by dendritic cells derived from monocytes cultured with GM- CSF + IL-2.

TL;DR: CCR4 is the specific receptor for TARC selectively expressed on T cells, and TARC is a specific functional ligand for CCR4, which is a selective chemoattractant for T cells that express a class of receptors binding TARC with high affinity and specificity.

TL;DR: GPR-CY4 is the specific receptor for LARC expressed selectively on lymphocytes, and LARC is a unique functional ligand for GPR-Y4, which is proposed to be designated as CCR6.

TL;DR: The entire cDNA sequence which encodes a highly basic polypeptide of 134 amino acids total with a putative signal peptide of 23 amino acids was determined and designated as SLC fromsecondary lymphoid-tissuechemokine, a novel CC chemokine specific for lymphocytes.