K
Kunio Hieshima
Researcher at Kumamoto University
Publications - 11
Citations - 3307
Kunio Hieshima is an academic researcher from Kumamoto University. The author has contributed to research in topics: C-C chemokine receptor type 6 & CC chemokine receptors. The author has an hindex of 11, co-authored 11 publications receiving 3170 citations.
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Journal ArticleDOI
Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion
Toshio Imai,Kunio Hieshima,Christopher Haskell,Masataka Baba,Morio Nagira,Miyuki Nishimura,Mayumi Kakizaki,Shin Takagi,Hisayuki Nomiyama,Thomas J. Schall,Osamu Yoshie +10 more
TL;DR: Fractalkine and CX3CR1 represent new types of leukocyte trafficking regulators, performing both adhesive and chemotactic functions.
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Identification of CCR6, the Specific Receptor for a Novel Lymphocyte-directed CC Chemokine LARC
Masataka Baba,Toshio Imai,Miyuki Nishimura,Mayumi Kakizaki,Shin Takagi,Kunio Hieshima,Hisayuki Nomiyama,Osamu Yoshie +7 more
TL;DR: GPR-CY4 is the specific receptor for LARC expressed selectively on lymphocytes, and LARC is a unique functional ligand for GPR-Y4, which is proposed to be designated as CCR6.
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Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7.
Ryu Yoshida,Toshio Imai,Kunio Hieshima,Jun Kusuda,Masataka Baba,Motoji Kitaura,Miyuki Nishimura,Mayumi Kakizaki,Hisayuki Nomiyama,Osamu Yoshie +9 more
TL;DR: ELC is a highly specific ligand for EBI1, which is known to be expressed in activated B and T lymphocytes and strongly up-regulated in B cells infected with Epstein-Barr virus and T cellsinfected with herpesvirus 6 or 7, and is proposed to be designated as CCR7.2 where the genes for CC chemokines are clustered.
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Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2
Kunio Hieshima,Toshio Imai,Ghislain Opdenakker,Jo Van Damme,Jun Kusuda,Hajime Tei,Yoshiyuki Sakaki,Kiyoshi Takatsuki,Retsu Miura,Osamu Yoshie,Hisayuki Nomiyama +10 more
TL;DR: This chemokine was mainly expressed in liver among various tissues and strongly induced in several human cell lines by phorbol myristate acetate and may represent a new group of CC chemokines localized on chromosome 2.
Journal ArticleDOI
Molecular Cloning of a Novel Human CC Chemokine Secondary Lymphoid-Tissue Chemokine That Is a Potent Chemoattractant for Lymphocytes and Mapped to Chromosome 9p13
Morio Nagira,Toshio Imai,Kunio Hieshima,Jun Kusuda,Maaret Ridanpää,Shin Takagi,Miyuki Nishimura,Mayumi Kakizaki,Hisayuki Nomiyama,Osamu Yoshie +9 more
TL;DR: The entire cDNA sequence which encodes a highly basic polypeptide of 134 amino acids total with a putative signal peptide of 23 amino acids was determined and designated as SLC fromsecondary lymphoid-tissuechemokine, a novel CC chemokine specific for lymphocytes.