M
Morio Nagira
Publications - 14
Citations - 3074
Morio Nagira is an academic researcher. The author has contributed to research in topics: CC chemokine receptors & Chemokine. The author has an hindex of 9, co-authored 9 publications receiving 2941 citations.
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Journal ArticleDOI
Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion
Toshio Imai,Kunio Hieshima,Christopher Haskell,Masataka Baba,Morio Nagira,Miyuki Nishimura,Mayumi Kakizaki,Shin Takagi,Hisayuki Nomiyama,Thomas J. Schall,Osamu Yoshie +10 more
TL;DR: Fractalkine and CX3CR1 represent new types of leukocyte trafficking regulators, performing both adhesive and chemotactic functions.
Journal ArticleDOI
Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine
Toshio Imai,Morio Nagira,Shin Takagi,Mayumi Kakizaki,Miyuki Nishimura,Jian-bin Wang,Patrick W. Gray,Kouji Matsushima,Osamu Yoshie +8 more
TL;DR: It is demonstrated that the T cell-directed CC chemokine thymus and activation-regulated Chemokine (TARC) was abundantly produced by monocytes treated with granulocyte macrophage colony stimulating factor (GM-CSF) or IL-3, especially in the presence of IL-4 and by dendritic cells derived from monocytes cultured with GM- CSF + IL-2.
Journal ArticleDOI
Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7.
TL;DR: It is shown that SLC is a high affinity functional ligand for chemokine receptor 7 (CCR7) that is expressed on T and B lymphocytes and a known receptor for ELC, a genetically and functionally highly related subgroup of CC chemokines.
Journal ArticleDOI
Molecular Cloning of a Novel Human CC Chemokine Secondary Lymphoid-Tissue Chemokine That Is a Potent Chemoattractant for Lymphocytes and Mapped to Chromosome 9p13
Morio Nagira,Toshio Imai,Kunio Hieshima,Jun Kusuda,Maaret Ridanpää,Shin Takagi,Miyuki Nishimura,Mayumi Kakizaki,Hisayuki Nomiyama,Osamu Yoshie +9 more
TL;DR: The entire cDNA sequence which encodes a highly basic polypeptide of 134 amino acids total with a putative signal peptide of 23 amino acids was determined and designated as SLC fromsecondary lymphoid-tissuechemokine, a novel CC chemokine specific for lymphocytes.
Journal ArticleDOI
A lymphocyte‐specific CC chemokine, secondary lymphoid tissue chemokine (SLC), is a highly efficient chemoattractant for B cells and activated T cells
Morio Nagira,Toshio Imai,Ryu Yoshida,Shin Takagi,Makoto Iwasaki,Masataka Baba,Youichi Tabira,Junji Akagi,Hisayuki Nomiyama,Osamu Yoshie +9 more
TL;DR: SLC is the first CC chemokine with a strong chemotactic activity on fresh B cells and among T cell types and subsets, SLC broadly attracted CD4+ and CD8+ cells,CD45RO– (naive) and CD45RO+ (memory) cells, and CD26high (activated) andCD26low/− (resting) cells.