S
Shingo Tsuji
Researcher at University of Tokyo
Publications - 46
Citations - 2115
Shingo Tsuji is an academic researcher from University of Tokyo. The author has contributed to research in topics: Hepatocellular carcinoma & DNA methylation. The author has an hindex of 16, co-authored 46 publications receiving 1755 citations.
Papers
More filters
Journal ArticleDOI
Trans-ancestry mutational landscape of hepatocellular carcinoma genomes
Yasushi Totoki,Kenji Tatsuno,Kyle R. Covington,Hiroki R. Ueda,Chad J. Creighton,Mamoru Kato,Shingo Tsuji,Lawrence A. Donehower,Betty L. Slagle,Hiromi Nakamura,Shogo Yamamoto,Eve Shinbrot,Natsuko Hama,Megan Lehmkuhl,Fumie Hosoda,Yasuhito Arai,Kim Walker,Mahmoud Dahdouli,Kengo Gotoh,Genta Nagae,Marie-Claude Gingras,Donna M. Muzny,Hidenori Ojima,Kazuaki Shimada,Yutaka Midorikawa,John A. Goss,Ronald T. Cotton,Akimasa Hayashi,Junji Shibahara,Shumpei Ishikawa,Jacfranz J. Guiteau,Mariko Tanaka,Tomoko Urushidate,Shoko Ohashi,Naoko Okada,Harsha Doddapaneni,Min Wang,Yiming Zhu,Huyen Dinh,Takuji Okusaka,Norihiro Kokudo,Tomoo Kosuge,Tadatoshi Takayama,Masashi Fukayama,Richard A. Gibbs,David A. Wheeler,Hiroyuki Aburatani,Tatsuhiro Shibata +47 more
TL;DR: A combination of hotspot TERT promoter mutation, TERT focal amplification and viral genome integration occurs in more than 68% of cases, implicating TERT as a central and ancestry-independent node of hepatocarcinogenesis.
Journal ArticleDOI
Three DNA Methylation Epigenotypes in Human Colorectal Cancer
Koichi Yagi,Kiwamu Akagi,Hiroshi Hayashi,Genta Nagae,Shingo Tsuji,Takayuki Isagawa,Yutaka Midorikawa,Yoji Nishimura,Hirohiko Sakamoto,Yasuyuki Seto,Hiroyuki Aburatani,Atsushi Kaneda +11 more
TL;DR: Three methylation epigenotypes exist in colorectal cancer, and suitable classification markers have been developed, and intermediate-methylation epigenotype with KRAS-mutation(+) correlated with worse prognosis.
Journal ArticleDOI
Mechanistic Background and Clinical Applications of Indocyanine Green Fluorescence Imaging of Hepatocellular Carcinoma
Takeaki Ishizawa,Koichi Masuda,Yasuteru Urano,Yoshikuni Kawaguchi,Shouichi Satou,Junichi Kaneko,Kiyoshi Hasegawa,Junji Shibahara,Masashi Fukayama,Shingo Tsuji,Yutaka Midorikawa,Hiroyuki Aburatani,Norihiro Kokudo +12 more
TL;DR: Preserved portal uptake in differentiated HCC cells by NTCP and OATP8 with concomitant biliary excretion disorders causes accumulation of ICG in the cancerous tissues after preoperative intravenous administration, which enables highly sensitive identification of HCC by intraoperative ICG fluorescence imaging.
Journal ArticleDOI
H3F3A K27M mutations in thalamic gliomas from young adult patients
Koki Aihara,Akitake Mukasa,Kengo Gotoh,Kuniaki Saito,Genta Nagae,Shingo Tsuji,Kenji Tatsuno,Shogo Yamamoto,Shunsaku Takayanagi,Yoshitaka Narita,Soichiro Shibui,Hiroyuki Aburatani,Nobuhito Saito +12 more
TL;DR: It was found that high-grade thalamic gliomas from young adults, like those from children and adolescents, frequently had H3F3A K27M, which is similar to those of hemispheric glioblastomas.
Journal ArticleDOI
PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer
Teruyuki Sato,Atsushi Kaneda,Atsushi Kaneda,Shingo Tsuji,Takayuki Isagawa,Shogo Yamamoto,Takanori Fujita,Ryota Yamanaka,Yukiko Tanaka,Toshihiro Nukiwa,Victor Márquez,Yuichi Ishikawa,Masakazu Ichinose,Hiroyuki Aburatani +13 more
TL;DR: In this article, expression array analysis of 23 small cell lung cancer (SCLC) cases and 42 normal tissues revealed that EZH2 and other PRC2 members were highly expressed in SCLC.