M
Mariko Tanaka
Researcher at University of Tokyo
Publications - 62
Citations - 1836
Mariko Tanaka is an academic researcher from University of Tokyo. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 16, co-authored 43 publications receiving 1417 citations.
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Journal ArticleDOI
Trans-ancestry mutational landscape of hepatocellular carcinoma genomes
Yasushi Totoki,Kenji Tatsuno,Kyle R. Covington,Hiroki R. Ueda,Chad J. Creighton,Mamoru Kato,Shingo Tsuji,Lawrence A. Donehower,Betty L. Slagle,Hiromi Nakamura,Shogo Yamamoto,Eve Shinbrot,Natsuko Hama,Megan Lehmkuhl,Fumie Hosoda,Yasuhito Arai,Kim Walker,Mahmoud Dahdouli,Kengo Gotoh,Genta Nagae,Marie-Claude Gingras,Donna M. Muzny,Hidenori Ojima,Kazuaki Shimada,Yutaka Midorikawa,John A. Goss,Ronald T. Cotton,Akimasa Hayashi,Junji Shibahara,Shumpei Ishikawa,Jacfranz J. Guiteau,Mariko Tanaka,Tomoko Urushidate,Shoko Ohashi,Naoko Okada,Harsha Doddapaneni,Min Wang,Yiming Zhu,Huyen Dinh,Takuji Okusaka,Norihiro Kokudo,Tomoo Kosuge,Tadatoshi Takayama,Masashi Fukayama,Richard A. Gibbs,David A. Wheeler,Hiroyuki Aburatani,Tatsuhiro Shibata +47 more
TL;DR: A combination of hotspot TERT promoter mutation, TERT focal amplification and viral genome integration occurs in more than 68% of cases, implicating TERT as a central and ancestry-independent node of hepatocarcinogenesis.
Journal ArticleDOI
Integrins play a critical role in mechanical stress-induced p38 MAPK activation.
Ryuichi Aikawa,Toshio Nagai,Sumiyo Kudoh,Yunzeng Zou,Mariko Tanaka,Masahito Tamura,Hiroshi Akazawa,Hiroyuki Takano,Ryozo Nagai,Issei Komuro +9 more
TL;DR: The results suggest that mechanical stress activates p38 MAPK and induces cardiac hypertrophy through the integrin-FAK-Src-Ras pathway in cardiac myocytes.
Journal ArticleDOI
Slow pull versus suction in endoscopic ultrasound-guided fine-needle aspiration of pancreatic solid masses.
Yousuke Nakai,Hiroyuki Isayama,Kenneth J. Chang,Natsuyo Yamamoto,Tsuyoshi Hamada,Rie Uchino,Suguru Mizuno,Koji Miyabayashi,Keisuke Yamamoto,Kazumichi Kawakubo,Hirofumi Kogure,Takashi Sasaki,Kenji Hirano,Mariko Tanaka,Minoru Tada,Masashi Fukayama,Kazuhiko Koike +16 more
TL;DR: The slow-pull technique was associated with less contamination with blood and can potentially increase the diagnostic yield compared with the suction technique in EUS-FNA of pancreatic solid masses, especially with a 25-gauge FNA needle.
Journal ArticleDOI
Long-term Risk of Malignancy in Branch-Duct Intraductal Papillary Mucinous Neoplasms
Hiroki Oyama,Minoru Tada,Kaoru Takagi,Kaoru Takagi,Keisuke Tateishi,Tsuyoshi Hamada,Yousuke Nakai,Ryunosuke Hakuta,Hideaki Ijichi,Kazunaga Ishigaki,Sachiko Kanai,Hirofumi Kogure,Suguru Mizuno,Kei Saito,Tomotaka Saito,Tatsuya Sato,Tatsunori Suzuki,Naminatsu Takahara,Yasuyuki Morishita,Junichi Arita,Kiyoshi Hasegawa,Mariko Tanaka,Masashi Fukayama,Kazuhiko Koike +23 more
TL;DR: In a large long-term study of patients with branch-duct IPMNs, the 5-year incidence rate of pancreatic malignancy is found to be 3.3%, reaching 15% at 15 years after IPMN diagnosis.
Journal ArticleDOI
CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity.
Naoto Fujiwara,Hayato Nakagawa,Kenichiro Enooku,Yotaro Kudo,Yuki Hayata,Takuma Nakatsuka,Yasuo Tanaka,Ryosuke Tateishi,Yohko Hikiba,Kento Misumi,Mariko Tanaka,Akimasa Hayashi,Junji Shibahara,Masashi Fukayama,Junichi Arita,Kiyoshi Hasegawa,Hadassa Hirschfield,Yujin Hoshida,Yoshihiro Hirata,Motoyuki Otsuka,Keisuke Tateishi,Kazuhiko Koike +21 more
TL;DR: In obesity-driven and NASH-driven HCC, metabolic reprogramming mediated by the downregulation of CPT2 enables HCC cells to escape lipotoxicity and promotes hepatocarcinogenesis.