T
Takayuki Isagawa
Researcher at Nagasaki University
Publications - 44
Citations - 2610
Takayuki Isagawa is an academic researcher from Nagasaki University. The author has contributed to research in topics: Cancer & Cellular differentiation. The author has an hindex of 21, co-authored 41 publications receiving 2112 citations. Previous affiliations of Takayuki Isagawa include University of Tokyo & Jichi Medical University.
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Journal ArticleDOI
RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock
Jean-Michel Fustin,Masao Doi,Yoshiaki Yamaguchi,Hayashi Hida,Shinichi Nishimura,Minoru Yoshida,Takayuki Isagawa,Masaki Suimye Morioka,Hideaki Kakeya,Ichiro Manabe,Hitoshi Okamura +10 more
TL;DR: It is reported that inhibition of transmethylation reactions elongates the circadian period and methylation inhibition causes widespread changes in the transcription of the RNA processing machinery, associated with m(6)A-RNA methylation.
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HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity
Hiroaki Semba,Norihiko Takeda,Takayuki Isagawa,Yuki Sugiura,Kurara Honda,Masaki Wake,Hidenobu Miyazawa,Yoshifumi Yamaguchi,Masayuki Miura,Masayuki Miura,Dana M. R. Jenkins,Hyunsung Choi,Jung Whan Kim,Masataka Asagiri,Andrew S. Cowburn,Hajime Abe,Katsura Soma,Katsuhiro Koyama,Manami Katoh,Keimon Sayama,Nobuhito Goda,Randall S. Johnson,Ichiro Manabe,Ryozo Nagai,Issei Komuro +24 more
TL;DR: It is shown that HIF-1α-PDK1-mediated metabolic changes occur in mild hypoxia, where mitochondrial cytochrome c oxidase activity is unimpaired, suggesting a mode of glycolytic reprogramming.
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Three DNA Methylation Epigenotypes in Human Colorectal Cancer
Koichi Yagi,Kiwamu Akagi,Hiroshi Hayashi,Genta Nagae,Shingo Tsuji,Takayuki Isagawa,Yutaka Midorikawa,Yoji Nishimura,Hirohiko Sakamoto,Yasuyuki Seto,Hiroyuki Aburatani,Atsushi Kaneda +11 more
TL;DR: Three methylation epigenotypes exist in colorectal cancer, and suitable classification markers have been developed, and intermediate-methylation epigenotype with KRAS-mutation(+) correlated with worse prognosis.
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PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer
Teruyuki Sato,Atsushi Kaneda,Atsushi Kaneda,Shingo Tsuji,Takayuki Isagawa,Shogo Yamamoto,Takanori Fujita,Ryota Yamanaka,Yukiko Tanaka,Toshihiro Nukiwa,Victor Márquez,Yuichi Ishikawa,Masakazu Ichinose,Hiroyuki Aburatani +13 more
TL;DR: In this article, expression array analysis of 23 small cell lung cancer (SCLC) cases and 42 normal tissues revealed that EZH2 and other PRC2 members were highly expressed in SCLC.
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Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis
Ewelina Krzywinska,Chahrazade Kantari-Mimoun,Yann M. Kerdiles,Michal Sobecki,Takayuki Isagawa,Dagmar Gotthardt,Magali Castells,Johannes Haubold,Corinne Millien,Thomas Viel,Bertrand Tavitian,Norihiko Takeda,Joachim Fandrey,Eric Vivier,Veronika Sexl,Christian Stockmann,Christian Stockmann +16 more
TL;DR: The authors show that HIF-1α deletion in NK cells impairs NK cytotoxic activity but inhibit tumour growth by decreasing the infiltration of NK cells that express angiostatic soluble VEGFR-1, thus resulting in non-functional angiogenesis.