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Shinichi Sekine
Researcher at Osaka University
Publications - 32
Citations - 897
Shinichi Sekine is an academic researcher from Osaka University. The author has contributed to research in topics: Nasal administration & Antigen. The author has an hindex of 14, co-authored 32 publications receiving 738 citations. Previous affiliations of Shinichi Sekine include University of Alabama at Birmingham.
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Journal ArticleDOI
Quantitative detection of periodontal pathogens using real-time polymerase chain reaction with TaqMan probes.
Masae Kuboniwa,Atsuo Amano,K. R. Kimura,Shinichi Sekine,S. Kato,Yumiko Yamamoto,Nobuo Okahashi,T. Iida,Satoshi Shizukuishi +8 more
TL;DR: The results suggest that the present real-time PCR method with the designed probe/primer sets enabled sensitive detection of the six periodontal bacteria, and may also assist future microbial studies ofperiodontal diseases.
Journal ArticleDOI
Antibacterial Activity of Curcumin Against Periodontopathic Bacteria
Shusuke Izui,Shinichi Sekine,Kazuhiko Maeda,Masae Kuboniwa,Akihiko Takada,Atsuo Amano,Hideki Nagata +6 more
TL;DR: Curcumin possesses antibacterial activity against periodontopathic bacteria and may be a potent agent for preventing periodontal diseases.
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A combination of Flt3 ligand cDNA and CpG ODN as nasal adjuvant elicits NALT dendritic cells for prolonged mucosal immunity.
Tatsuya Fukuiwa,Shinichi Sekine,Ryoki Kobayashi,Hideaki Suzuki,Kosuke Kataoka,Rebekah S. Gilbert,Yuichi Kurono,Prosper N. Boyaka,Arthur M. Krieg,Jerry R. McGhee,Kohtaro Fujihashi +10 more
TL;DR: It is demonstrated that nasal delivery of a combined DNA adjuvant offers an attractive possibility for the development of an effective mucosal vaccine for the elderly.
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All-in-one microfluidic device for on-site diagnosis of pathogens based on an integrated continuous flow PCR and electrophoresis biochip
Zhenqing Li,Ruixue Ju,Shinichi Sekine,Dawei Zhang,Songlin Zhuang,Yoshinori Yamaguchi,Yoshinori Yamaguchi +6 more
TL;DR: A new method was proposed for automatic sample injection into the chip which can substitute the costly external precision syringe pump and not only achieves rapid DNA amplification and on-site PCR product detection, but also realizesautomatic sample injection.
Journal ArticleDOI
Ovalbumin-Protein σ1 M-Cell Targeting Facilitates Oral Tolerance With Reduction of Antigen-Specific CD4+ T Cells
Hideaki Suzuki,Shinichi Sekine,Kosuke Kataoka,Kosuke Kataoka,David W. Pascual,Massimo Maddaloni,Ryoki Kobayashi,K Fujihashi,Haruo Kozono,Jerry R. McGhee,Kohtaro Fujihashi +10 more
TL;DR: Results show that an FAE M-cell targeting protein Ag delivery system facilitates oral tolerance induction because of a reduction in Ag-specific CD4(+) T cells and increased levels of TGF-beta1 and IL-10 producing, CD25(+) CD4 (+) regulatory T cells in both systemic and mucosal lymphoid tissues.