Shinya Sugimoto

TL;DR: It is shown that human L GR5+ colorectal cancer cells serve as CSCs in growing cancer tissues and combined chemotherapy potentiates targeting of LGR5+ C SCs.

TL;DR: Functional heterogeneity of Wnt niche independency in PDAC that is non-genetically formed through tumor progression is revealed, and CRISPR-Cas9-based genome editing of PDAC driver genes demonstratedNon-genetic acquisition of WNT niche independence during pancreas tumorigenesis.

TL;DR: A refined organoid culture condition for intestinal epithelia is established that allows human intestinal organoids to concurrently undergo multi-differentiation and self-renewal and offers a viable strategy for modeling human intestinal tissues and diseases in an in vivo relevant context.

TL;DR: It is demonstrated that multifaceted genetic abnormalities render human GCs independent of the stem cell niche and highlight the validity of the genotype-phenotype screening strategy in gaining deeper understanding of human cancers.

TL;DR: A unique pattern of somatic mutagenesis in the inflamed epithelium of patients with ulcerative colitis is identified, and somatic mutations in components of the IL-17 signalling pathway are identified, which may confer a growth advantage to cells under inflammatory conditions.