Jihoon Kim

TL;DR: The applications, advantages and disadvantages of human organoids as models of development and disease and the challenges that have to be overcome for organoids to be able to substantially reduce the need for animal experiments are discussed.

TL;DR: It is demonstrated that multifaceted genetic abnormalities render human GCs independent of the stem cell niche and highlight the validity of the genotype-phenotype screening strategy in gaining deeper understanding of human cancers.

TL;DR: This work presents CRISPR–FLIP, a strategy that provides an efficient, rapid and scalable method for biallelic conditional gene knockouts in diploid or aneuploid cells, such as pluripotent stem cells, 3D organoids and cell lines, by co-delivery of CRISpr–Cas9 and a universal conditional intronic cassette.

TL;DR: Good strain transmission at the incoherent interface between a strain-released film of epitaxially grown ferromagnetic La 0.7 Sr 0.3 MnO 3 and an electroactive substrate of ferroelectric 0.68Pb(Mg 1/3 Nb 2/3 )O 3 -0.32PbTiO 3 is demonstrated.

TL;DR: The data suggest that RNF43 mutations cooperate with KRAS mutations to promote multi-step tumorigenesis via the Wnt-Ras-p53 axis in human colon cancers, and phosphomimetic substitutions of the serine trio restored the tumour suppressive activity of extracellular oncogenic mutants.