S
Showbu Sato
Researcher at Mitsubishi
Publications - 4
Citations - 367
Showbu Sato is an academic researcher from Mitsubishi. The author has contributed to research in topics: Synaptic vesicle & Cilium. The author has an hindex of 3, co-authored 4 publications receiving 333 citations.
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Journal ArticleDOI
SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release
Ikuko Yao,Hiroshi Takagi,Hiroshi Ageta,Tomoaki Kahyo,Showbu Sato,Ken Hatanaka,Yoshiyuki Fukuda,Tomoki Chiba,Nobuhiro Morone,Shigeki Yuasa,Kaoru Inokuchi,Toshihisa Ohtsuka,Grant R. MacGregor,Keiji Tanaka,Mitsutoshi Setou,Mitsutoshi Setou +15 more
TL;DR: In neurons from Scrapper-knockout (SCR-KO) mice, RIM1 had a longer half-life with significant reduction in ubiquitination, indicating that SCRAPPER is the predominant ubiquitin ligase that mediates RIM 1 degradation.
Journal ArticleDOI
Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry
Koji Ikegami,Showbu Sato,Kenji Nakamura,Lawrence E. Ostrowski,Mitsutoshi Setou,Mitsutoshi Setou +5 more
TL;DR: It is reported here that the beating asymmetry is crucial for ciliary function and requires tubulin glutamylation, a unique posttranslational modification that is highly abundant in cilia.
Journal ArticleDOI
Transmembrane and Ubiquitin-Like Domain-Containing Protein 1 (Tmub1/HOPS) Facilitates Surface Expression of GluR2-Containing AMPA Receptors
Hyun-Jeong Yang,Hyun-Jeong Yang,Hiroshi Takagi,Yoshiyuki Konishi,Hiroshi Ageta,Koji Ikegami,Ikuko Yao,Showbu Sato,Ken Hatanaka,Kaoru Inokuchi,Dae Hyun Seog,Mitsutoshi Setou,Mitsutoshi Setou +12 more
TL;DR: Observations show that the Tmub1/HOPS plays a role in regulating basal synaptic transmission; it contributes to maintain the synaptic surface number of the GluR2-containing AMPARs by facilitating the recycling of GLUR2 to the plasma membrane.
Journal ArticleDOI
SCRAPPER-Dependent Ubiquitination of Active Zone Protein RIM1 Regulates Synaptic Vesicle Release (DOI:10.1016/j.cell.2007.06.052)
Ikuko Yao,Hiroshi Takagi,Hiroshi Ageta,Tomoaki Kahyo,Showbu Sato,Ken Hatanaka,Yoshiyuki Fukuda,Tomoki Chiba,Nobuhiro Morone,Shigeki Yuasa,Kaoru Inokuchi,Toshihisa Ohtsuka,Grant R. MacGregor,Keiji Tanaka,Mitsutoshi Setou +14 more