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Shu Hsia Chen
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 96
Citations - 9757
Shu Hsia Chen is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Immune system & Myeloid-derived Suppressor Cell. The author has an hindex of 40, co-authored 76 publications receiving 8499 citations. Previous affiliations of Shu Hsia Chen include Houston Methodist Hospital & Mount Sinai Hospital.
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Journal ArticleDOI
Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
Vincenzo Bronte,Sven Brandau,Shu Hsia Chen,Mario P. Colombo,Alan B. Frey,Tim F. Greten,Susanna Mandruzzato,Peter J. Murray,Augusto C. Ochoa,Suzanne Ostrand-Rosenberg,Paulo C. Rodriguez,Antonio Sica,Viktor Umansky,Viktor Umansky,Robert H. Vonderheide,Dmitry I. Gabrilovich +15 more
TL;DR: The authors identify the challenges and proposed set of minimal reporting guidelines for mouse and human MDSC are a heterogeneous population expanded in cancer and other chronic inflammatory conditions.
Journal ArticleDOI
Gr-1+CD115+ Immature Myeloid Suppressor Cells Mediate the Development of Tumor-Induced T Regulatory Cells and T-Cell Anergy in Tumor-Bearing Host
Bo Huang,Ping-Ying Pan,Qingsheng Li,Alice I. Sato,David E. Levy,Jonathan S. Bromberg,Celia M. Divino,Shu Hsia Chen +7 more
TL;DR: Evidence is provided that Gr-1(+)CD115(+) MSC can mediate the development of Treg in tumor-bearing mice and show a novel immune suppressive mechanism by which MSCs can suppress antitumor responses.
Journal ArticleDOI
The terminology issue for myeloid-derived suppressor cells.
Dmitry I. Gabrilovich,Vincenzo Bronte,Shu Hsia Chen,Mario P. Colombo,Augusto C. Ochoa,Suzanne Ostrand-Rosenberg,Hans Schreiber +6 more
TL;DR: This report continued a series of recent articles published in Cancer Research, which provided strong evidence that antigen-specific immunosuppression by Gr-1+CD11b+ myeloid cells, which was mediated by the expression of CD80, is real.
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The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies.
Junko Ozao-Choy,Ge Ma,Johnny Kao,George X. Wang,Marcia Meseck,Max Sung,Myron Schwartz,Celia M. Divino,Ping-Ying Pan,Shu Hsia Chen +9 more
TL;DR: The data suggest that sunitinib can be used to reverse immune suppression and as a potentially useful adjunct for enhancing the efficacy of immune-based cancer therapy for advanced malignancies.
Journal ArticleDOI
Immune stimulatory receptor CD40 is required for T-cell suppression and T regulatory cell activation mediated by myeloid-derived suppressor cells in cancer.
Ping-Ying Pan,Ge Ma,Kaare J. Weber,Junko Ozao-Choy,George X. Wang,Bingjiao Yin,Celia M. Divino,Shu Hsia Chen +7 more
TL;DR: It is demonstrated that expression of the immune stimulatory receptor CD40 on MDSCs is required to induce T-cell tolerance and Treg accumulation and blockade of CD40-CD40L interaction between MDSC and T Reg may provide a new strategy to ablate tumoral immune suppression and thereby heighten responses to immunotherapy.