Shu-Ming Huang

TL;DR: In this paper, the authors studied wild-type and P301S mutant human tau transgenic (Tg) mice and found that tangle formation was preceded by microglial activation.

TL;DR: The results indicate that the aging-induced downregulation of somatostatin expression may be a trigger for Aβ accumulation leading to late-onset sporadic Alzheimer disease, and suggest that som atostatin receptors may be pharmacological-target candidates for prevention and treatment of Alzheimer disease.

TL;DR: Calpastatin-knockout mice showed decreased locomotor activity under stressful environments, and decreased acoustic startle response, but there was no significant change in hippocampus-dependent memory function, suggesting that calpastatin is likely to be more closely associated with affective rather than cognitive aspects of brain function.

TL;DR: Findings suggest that AD-EFV could ameliorate Aβ induced cognitive dysfunction through two underlying mechanisms: AD- EFV enhances the cerebral cholinergic function by increasing the secretion of ACh and enhancing the ChAT activity, and AD-EfV protects the brain neurons from A β induced apoptosis via activating the p-ERK and Bcl-2 signaling and suppressing the Bax pathways.

TL;DR: It is revealed that Kai Xin San facilitates hippocampal Aβ degradation and increases IDE expression, which leads, at least in part, to the alleviation of hippocampal neuron injury in rats.