J
Jun Maeda
Researcher at National Institute of Radiological Sciences
Publications - 103
Citations - 6342
Jun Maeda is an academic researcher from National Institute of Radiological Sciences. The author has contributed to research in topics: Tauopathy & Dopamine. The author has an hindex of 33, co-authored 103 publications receiving 5613 citations.
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Journal ArticleDOI
Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
Yasumasa Yoshiyama,Makoto Higuchi,Bin Zhang,Shu-Ming Huang,Nobuhisa Iwata,Takaomi C. Saido,Jun Maeda,Tetsuya Suhara,John Q. Trojanowski,Virginia M.-Y. Lee +9 more
TL;DR: In this paper, the authors studied wild-type and P301S mutant human tau transgenic (Tg) mice and found that tangle formation was preceded by microglial activation.
Journal ArticleDOI
Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls
Masahiro Maruyama,Hitoshi Shimada,Tetsuya Suhara,Hitoshi Shinotoh,Bin Ji,Jun Maeda,Ming-Rong Zhang,John Q. Trojanowski,Virginia M.-Y. Lee,Maiko Ono,Kazuto Masamoto,Harumasa Takano,Naruhiko Sahara,Naruhiko Sahara,Nobuhisa Iwata,Nobuyuki Okamura,Shozo Furumoto,Yukitsuka Kudo,Qing Chang,Takaomi C. Saido,Akihiko Takashima,Jada Lewis,Ming Kuei Jang,Ichio Aoki,Hiroshi Ito,Makoto Higuchi +25 more
TL;DR: A class of tau ligands, phenyl/pyridinyl-butadienyl-benzothiazoles/benZothiazoliums (PBBs), for visualizing diverse tau inclusions in brains of living patients with AD or non-AD tauopathies and animal models of these disorders are developed.
Journal ArticleDOI
Longitudinal, Quantitative Assessment of Amyloid, Neuroinflammation, and Anti-Amyloid Treatment in a Living Mouse Model of Alzheimer's Disease Enabled by Positron Emission Tomography
Jun Maeda,Bin Ji,Toshiaki Irie,Takami Tomiyama,Masahiro Maruyama,Takashi Okauchi,Matthias Staufenbiel,Nobuhisa Iwata,Maiko Ono,Takaomi C. Saido,Kazutoshi Suzuki,Hiroshi Mori,Makoto Higuchi,Tetsuya Suhara +13 more
TL;DR: The results support the usefulness of the small animal-dedicated PET system in conjunction with high-specific radioactivity probes and appropriate Tg models not only for clarifying the mechanistic properties of amyloidogenesis in mouse models but also for preclinical tests of emerging diagnostic and therapeutic approaches to AD.
Journal ArticleDOI
Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders.
Nobuyuki Yamasaki,Motoko Maekawa,Katsunori Kobayashi,Yasushi Kajii,Jun Maeda,Miho Soma,Keizo Takao,Koichi Tanda,Koji Ohira,Keiko Toyama,Kouji Kanzaki,Kohji Fukunaga,Yusuke Sudo,Hiroshi Ichinose,Masashi Ikeda,Masashi Ikeda,Nakao Iwata,Norio Ozaki,Hidenori Suzuki,Makoto Higuchi,Tetsuya Suhara,Shigeki Yuasa,Tsuyoshi Miyakawa +22 more
TL;DR: It is proposed that an "immature DG" in adulthood might induce alterations in behavior and serve as a promising candidate endophenotype of schizophrenia and other human psychiatric disorders.
Journal ArticleDOI
Functional brain mapping of monkey tool use.
Shigeru Obayashi,Shigeru Obayashi,Shigeru Obayashi,Tetsuya Suhara,Koichi Kawabe,Takashi Okauchi,Jun Maeda,Yoshihide Akine,Hirotaka Onoe,Atsushi Iriki +9 more
TL;DR: In this article, the authors explored tool use-induced activation within the intraparietal area and elsewhere in the alert monkey brain using positron emission tomography (PET) and found a significant increase in cerebral blood flow in corresponding intra-parietal region, basal ganglia, presupplementary motor area, premotor cortex, and cerebellum.