Journal ArticleDOI
Resveratrol: Review on its discovery, anti-leukemia effects and pharmacokinetics
Xiangtao Huang,Xi Li,Mingling Xie,Zhen Huang,Yongxiu Huang,Guixian Wu,Zhi-rong Peng,Yanni Sun,Qian-liang Ming,Yan-xia Liu,Jieping Chen,Shuangnian Xu +11 more
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TLDR
This review summarized resveratrol's discovery, sources and isolation methods, administration methods, effects in different types of leukemia, pharmacokinetics and toxicities, aiming to exploit resver atrol as a potential drug candidate for anti-leukemia.About:
This article is published in Chemico-Biological Interactions.The article was published on 2019-06-01. It has received 61 citations till now. The article focuses on the topics: Resveratrol.read more
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Novel approaches for co-encapsulation of probiotic bacteria with bioactive compounds, their health benefits and functional food product development: A review
TL;DR: It is emphasized that co-encapsulation of bioactive compounds and probiotic bacteria in a single product provides synergistic health benefits and enhances the bioactivity of individual components thus improve the adherence of probiotics to the intestinal wall during digestion.
Journal ArticleDOI
Natural products and their derivatives: Promising modulators of tumor immunotherapy.
TL;DR: A deep generalization, analysis, and summarization of the previous achievements, recent progress, and the bottlenecks in the development of natural products as tumor immunotherapy are performed.
Journal ArticleDOI
Grape (Vitis vinifera L.) Seed Oil: A Functional Food from the Winemaking Industry
María E. Martín,Elena Grao-Cruces,María del Carmen Millán-Linares,Sergio Montserrat-de la Paz +3 more
TL;DR: This review focuses on the advantages of grape seed oil intake in the authors' diet regarding its chemical composition in industries not related to wine production and the economic and environmental impact of oil production.
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Resveratrol Modulates Transforming Growth Factor-Beta (TGF-β) Signaling Pathway for Disease Therapy: A New Insight into Its Pharmacological Activities.
Milad Ashrafizadeh,Masoud Najafi,Sima Orouei,Amirhossein Zabolian,Hossein Saleki,Negar Azami,Negin Sharifi,Kiavash Hushmandi,Ali Zarrabi,Kwang Seok Ahn +9 more
TL;DR: Light is shed on the protective effects of Res mediated via the modulation of TGF-β signaling to shed light on the protectiveness of this naturally occurring bioactive compound in the amelioration of diabetic complications.
Journal ArticleDOI
Natural Compounds for the Prevention and Treatment of Cardiovascular and Neurodegenerative Diseases.
Rosalba Leuci,Leonardo Brunetti,Viviana Poliseno,Antonio Laghezza,Fulvio Loiodice,Paolo Tortorella,Luca Piemontese +6 more
TL;DR: A review of the most recent literature regarding the discovery of secondary metabolites through isolation and structural elucidation, as well as the in vitro and/or in vivo evaluation of their biological effects is discussed in this article.
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Journal ArticleDOI
Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
Mei-Shiang Jang,Lining Cai,George Udeani,Karla Slowing,Cathy F. Thomas,Chris Beecher,Harry H. S. Fong,Norman R. Farnsworth,A. Douglas Kinghorn,Rajendra G. Mehta,Richard C. Moon,John M. Pezzuto +11 more
TL;DR: It is suggested that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.
Journal ArticleDOI
Therapeutic potential of resveratrol: the in vivo evidence.
Joseph A. Baur,David A. Sinclair +1 more
TL;DR: A comprehensive and critical review of the in vivo data on resveratrol is provided, and its potential as a therapeutic for humans is considered.
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High absorption but very low bioavailability of oral resveratrol in humans
TL;DR: The dietary polyphenol resveratrol has been shown to have chemopreventive activity against cardiovascular disease and a variety of cancers in model systems, but it is not clear whether the drug reaches the proposed sites of action in vivo after oral ingestion, especially in humans.
Journal Article
Role of Resveratrol in Prevention and Therapy of Cancer: Preclinical and Clinical Studies
Bharat B. Aggarwal,Anjana Bhardwaj,Rishi S. Aggarwal,Navindra P. Seeram,Shishir Shishodia,Yasunari Takada +5 more
TL;DR: In vivo, resveratrol blocks the multistep process of carcinogenesis at various stages: it blocks carcinogen activation by inhibiting aryl hydrocarbon-induced CYP1A1 expression and activity, and suppresses tumor initiation, promotion and progression.
Journal ArticleDOI
Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent
David J. Boocock,Guy Faust,Ketan R. Patel,Anna M. Schinas,Victoria Brown,Murray P. Ducharme,Tristan D. Booth,James A. Crowell,Marjorie Perloff,Andreas J. Gescher,William P. Steward,Dean E. Brenner +11 more
TL;DR: The results presented here intimate that consumption of high-dose resveratrol might be insufficient to elicit systemic levels commensurate with cancer chemopreventive efficacy, however, the high systemic levels of resver atrol conjugate metabolites suggest that their cancer chemosynthetic properties warrant investigation.