Shuichi Sakai

TL;DR: This work has created an immortalized line of fibroblasts lacking PPARgamma, which is used to show that C/EBPalpha has no ability to promote adipogenesis in the absence of PPARGamma, and indicates that C- EBPalpha and PPAR Gamble participate in a single pathway of fat cell development.

TL;DR: Data indicate that PPARγ plays a critical role in the regulation of cholesterol homeostasis by controlling the expression of a network of genes that mediate cholesterol efflux from cells and its transport in plasma.

TL;DR: CYP1B1-null mice, created by targeted gene disruption in embryonic stem cells, were born at the expected frequency from heterozygous matings with no observable phenotype as discussed by the authors.

TL;DR: PPAR and C/EBP are critical transcription factors in adipogenesis, but the precise role of these proteins has been difficult to ascertain because they positively regu-late each other’s expression.

TL;DR: Two point mutations in the human PPARalpha gene were found in the DNA binding domain at codons for amino acids 131 and 162 and it will be of great interest to determine whether these alleles are associated with differential response to fibrate therapy.