Shupei Wang

TL;DR: It is demonstrated that >90% of all macrophages in WAT of obese mice and humans are localized to dead adipocytes, where they fuse to form syncytia that sequester and scavenge the residual “free” adipocyte lipid droplet and ultimately form multinucleate giant cells, a hallmark of chronic inflammation.

TL;DR: The differential diagnosis of abnormalities of ketone body metabolism is summarized, as well as pertinent recent advances in research, to suggest the diagnosis of either hyperinsulinism or an inborn error of fat energy metabolism.

TL;DR: The lysosomal sialidase gene is mapped to human chromosome 6 (6p21.3), which is consistent with the previous chromosomal assignment of this gene in proximity to the HLA locus, and its cloning, sequencing and expression are reported.

TL;DR: Newly-recognized mediators of lipolysis include atrial natriuretic peptide, cyclic GMP, the ketone body 3-hydroxybutyrate, AMP kinase and mitogen-activated kinases.

TL;DR: The important role of HSL is demonstrated on skeletal muscle, heart, and liver glucose metabolism during hyperinsulinemic euglycemic clamps during high-fat or normal chow diet in awake, HSL-deficient (HSL-KO) mice.