Shwetha Srinivasan

TL;DR: With an improved surface passivation method, the cumbersome purification steps even for single molecule studies that demand high purity in the sample are obviated.

TL;DR: In this paper, the relative stability of the singlet and triplet states of paramagnetic diatomic molecules B 2, O 2 and Ge 2 was investigated inside a C 60 cage.

TL;DR: The authors showed that ligand binding induces intracellular conformational changes within monomeric, full-length epidermal growth factor receptor (EGFR) and implicate a series of electrostatic interactions in the conformational coupling and find the coupling is inhibited by targeted therapeutics and mutations that also inhibit phosphorylation.

TL;DR: Using single-molecule trapping of reaction intermediates, a method was developed that enabled us to perform one reaction at one site and simultaneously study the real-time dynamics of the catalytic pathway, proposing a new mechano-activated catalytic pathways.

TL;DR: In this article , the authors used a multidisciplinary approach involving single-molecule Förster resonance energy transfer, mutagenesis, and molecular dynamics simulations to isolate full-length, functional epidermal growth factor receptor (EGFR) in a nearphysiological environment.