Mohd Askandar Iqbal

TL;DR: Constant evidence suggests a critical role played by the low‐activity‐dimeric PKM2 in tumor progression, supported by the identification of mutations which result in the down‐regulation of its activity and tumorigenesis in a nude mouse model.

TL;DR: The study identifies new PKM2-mediated effects of insulin on cancer metabolism, thus, advancing the understanding of insulin’s role in cancer.

TL;DR: It is observed that resveratrol down-regulated PKM2 expression by inhibiting mTOR signaling and suppressed cancer metabolism, adjudged by decreased glucose uptake, lactate production and reduced anabolism (macromolecule synthesis) in various cancer cell lines.

TL;DR: This study provides the first evidence linking natural mutations in PKM2 with cancer, and demonstrates for the first time the possible predisposition of Bloom syndrome patients with impaired PKM1 activity to cancer and the importance of studying genetic variations inPKM2 in the future to understand their relevance in cancer in general.

TL;DR: The role of cellular metabolism in regulation of the epigenome is discussed and how epigenetic changes may contribute to establish cancer-specific metabolic features are discussed.