Farid Ahmad Siddiqui

TL;DR: It is shown that curcumin inhibits glucose uptake and lactate production (Warburg effect) in a variety of cancer cell lines by down-regulating PKM2 expression, via inhibition of mTOR-HIF1α axis, and PKM 2 over-expression abrogated the effects ofCurcumin, demonstrating that inhibition of Warburg effect by curcuming is PKM1-mediated.

TL;DR: The study identifies new PKM2-mediated effects of insulin on cancer metabolism, thus, advancing the understanding of insulin’s role in cancer.

TL;DR: The results highlight the importance of EGFR‐MYC‐TXNIP axis in regulating TNBC metabolism, demonstrate the anti‐TNBC activity of silibinin, and argue in favor of targeting metabolic vulnerabilities of TNBC, at least in combination with mainstay chemotherapeutic drugs, to effectively treat TNBC patients.

TL;DR: A modular and simple inhibitor redesign is engineered into prenyl-binding pocket inhibitors of PDE6D to increase resilience against ejection and could significantly advance the development of pharmacologically more potent compounds against PDE 6D and related targets, such as UNC119 in the future.

TL;DR: This study provides the first evidence linking natural mutations in PKM2 with cancer, and demonstrates for the first time the possible predisposition of Bloom syndrome patients with impaired PKM1 activity to cancer and the importance of studying genetic variations inPKM2 in the future to understand their relevance in cancer in general.