S
Siew-Lan Ang
Researcher at French Institute of Health and Medical Research
Publications - 19
Citations - 3561
Siew-Lan Ang is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Endoderm & Gastrulation. The author has an hindex of 18, co-authored 19 publications receiving 3459 citations. Previous affiliations of Siew-Lan Ang include Collège de France & National Institute for Medical Research.
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Journal ArticleDOI
A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain
TL;DR: It is demonstrated that Otx2 is required for proper development of the epiblast and patterning of the anterior brain in mice, and the idea of evolutionary conservation of the function of Otd/Otx genes in head development in flies and mice is supported.
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An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development.
Marc K. Saba-El-Leil,Francis D.J. Vella,Bertrand Vernay,Laure Voisin,Lan Chen,Nathalie Labrecque,Siew-Lan Ang,Sylvain Meloche +7 more
TL;DR: It is shown that disruption of the Erk2 locus leads to embryonic lethality early in mouse development after the implantation stage, and analysis of chimeric embryos showed that ErK2 functions in a cell‐autonomous manner during the development of extra‐embryonic cell lineages.
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Nodal Antagonists in the Anterior Visceral Endoderm Prevent the Formation of Multiple Primitive Streaks
Aitana Perea-Gomez,Francis D.J. Vella,William Shawlot,Mustapha Oulad-Abdelghani,Claire Chazaud,Chikara Meno,Véronique Pfister,Lan Chen,Elizabeth J. Robertson,Hiroshi Hamada,Richard R. Behringer,Siew-Lan Ang +11 more
TL;DR: These findings provide support for a model whereby Cerberus-like and Lefty1 in the anterior visceral endoderm restrict primitive streak formation to the posterior end of mouse embryos by antagonizing Nodal signaling, and both antagonists are also required for proper patterning of the primitive streak.
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Mammalian hairy and Enhancer of Split Homolog 1 Regulates Differentiation of Retinal Neurons and Is Essential for Eye Morphogenesis
Koichi Tomita,Makoto Ishibashi,Makoto Ishibashi,Kiyoshi Nakahara,Siew-Lan Ang,Shigetada Nakanishi,François Guillemot,Ryoichiro Kageyama +7 more
TL;DR: Evidence is provided that HES1 regulates differentiation of retinal neurons and is essential for eye morphogenesis.
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Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling
TL;DR: It is shown that in zebrafish, Sef functions as a feedback-induced antagonist of Ras/Raf/MEK/MAPK-mediated FGF signalling.