S
Sigal Pressman
Researcher at Northwestern University
Publications - 7
Citations - 374
Sigal Pressman is an academic researcher from Northwestern University. The author has contributed to research in topics: Argonaute & RNA. The author has an hindex of 4, co-authored 6 publications receiving 350 citations.
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Journal ArticleDOI
Silencing by small RNAs is linked to endosomal trafficking
Young Sik Lee,Sigal Pressman,Arlise P. Andress,Kevin Kim,Jamie L. White,Justin J. Cassidy,Xin Li,Xin Li,Kim Lubell,Do Hwan Lim,Ik Sang Cho,Kenji S. Nakahara,Kenji S. Nakahara,Jonathan B. Preall,Priya Bellare,Priya Bellare,Erik J. Sontheimer,Richard W. Carthew +17 more
TL;DR: It is suggested that the recycling of RISCs is promoted by MVBs, resulting in RISCs more effectively engaging with small RNA effectors and possibly target RNAs, and may provide a means to enhance the dynamics of RNA silencing in the cytoplasm.
Journal ArticleDOI
Microprocessor Recruitment to Elongating RNA Polymerase II Is Required for Differential Expression of MicroRNAs.
Victoria A. Church,Sigal Pressman,Mamiko Isaji,Mary Truscott,Nihal Terzi Cizmecioglu,Stephen Buratowski,Maxim V. Frolov,Richard W. Carthew +7 more
TL;DR: It is shown that Drosophila DGCR8 (Pasha) directly associates with the C-terminal domain of the RNA polymerase II elongation complex when it is phosphorylated by the Cdk9 kinase (pTEFb).
Journal ArticleDOI
A Systematic Genetic Screen to Dissect the MicroRNA Pathway in Drosophila.
TL;DR: A systematic screen designed to identify all Drosophila genes in ∼40% of the genome that function in the miRNA pathway suggests genetic screens that use clonal analysis can elucidate the miRNAs program and that ∼100 genes are required to execute the mi RNA program.
Journal ArticleDOI
SnapShot: Posttranscriptional Gene Silencing
TL;DR: Double-strand (ds)RNAs that are taken up exogenously, formed during viral replication, or generated from aberrant cellular RNAs are cut into 21–23 nucleotide siRNAs by Dicer in association with dsRNA-binding (dsRBD) protein.
Journal ArticleDOI
SnapShot: small RNA-mediated epigenetic modifications.
TL;DR: RITS recruits the RNA-directed RNA polymerase complex (RDRC) and Clr4, a histone methyltransferase that methylates histone H3 at lysine 9 (H3K9me), resulting in stable interaction of RITS and heterochromatic DNA.