S
Sigrid Cornelis
Researcher at Ghent University
Publications - 14
Citations - 1987
Sigrid Cornelis is an academic researcher from Ghent University. The author has contributed to research in topics: Internal ribosome entry site & Caspase. The author has an hindex of 11, co-authored 13 publications receiving 1836 citations. Previous affiliations of Sigrid Cornelis include Ablynx.
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Journal ArticleDOI
Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria
Ellen Wirawan,L Vande Walle,Kristof Kersse,Sigrid Cornelis,Sigrid Cornelis,Sofie Claerhout,Isabel Vanoverberghe,Ria Roelandt,R. De Rycke,Jelle Verspurten,Wim Declercq,Patrizia Agostinis,T Vanden Berghe,Saskia Lippens,Peter Vandenabeele +14 more
TL;DR: Findings point to a mechanism by which casp-dependent generation of Beclin-1-C creates an amplifying loop enhancing apoptosis upon growth factor withdrawal.
Journal ArticleDOI
RIP1, a kinase on the crossroads of a cell's decision to live or die
TL;DR: This review describes how RIP1 acts as a key integrator of signalling pathways initiated by stimulation of death receptors, bacterial or viral infection, genotoxic stress and T-cell homeostasis.
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Identification and characterization of a novel cell cycle-regulated internal ribosome entry site.
Sigrid Cornelis,Yanik Bruynooghe,Geertrui Denecker,Sofie Van Huffel,Sandrine A. Tinton,Rudi Beyaert +5 more
TL;DR: In this article, two PITSLRE protein kinase isoforms, namely p11O(PITSLRE) and p58(PitSLRE), are translated from a single transcript by initiation at alternative in-frame AUG codons.
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A role for hnRNP C1/C2 and Unr in internal initiation of translation during mitosis.
Bert Schepens,Sandrine A. Tinton,Yanik Bruynooghe,Eef Parthoens,Mira Haegman,Rudi Beyaert,Sigrid Cornelis +6 more
TL;DR: It is shown that UNR mRNA translation and UNR IRES activity are significantly increased during mitosis, and the existence of an IRES‐dependent cascade in mitosis comprising hnRNP C1/C2 proteins that stimulate Unr expression, and Unr, in turn, contributes to PITSLREIRES activity.
Journal ArticleDOI
The polypyrimidine tract-binding protein stimulates HIF-1α IRES-mediated translation during hypoxia
TL;DR: The data suggest that PTB plays a stimulatory role in the IRES-mediated translation of HIF-1α when oxygen supply is limited.