Identification and characterization of a novel cell cycle-regulated internal ribosome entry site.
Sigrid Cornelis,Yanik Bruynooghe,Geertrui Denecker,Sofie Van Huffel,Sandrine A. Tinton,Rudi Beyaert +5 more
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In this article, two PITSLRE protein kinase isoforms, namely p11O(PITSLRE) and p58(PitSLRE), are translated from a single transcript by initiation at alternative in-frame AUG codons.About:
This article is published in Molecular Cell.The article was published on 2000-04-01 and is currently open access. It has received 299 citations till now. The article focuses on the topics: Internal ribosome entry site & Translation (biology).read more
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Journal ArticleDOI
Internal ribosome entry sites in eukaryotic mRNA molecules
TL;DR: The molecular mechanisms of IRES-mediated initiation are discussed and how they are used by specific mRNAs to permit translation under physiological circumstances such as mitosis, apoptosis, hypoxia, and some viral infections when translation of most m RNAs is repressed.
Journal ArticleDOI
Does the ribosome translate cancer
TL;DR: Although many studies have correlated deregulation of protein biosynthesis with cancer, it remains to be established whether this translates directly into an increase in cancer susceptibility, and under what circumstances.
Journal ArticleDOI
Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria
Ellen Wirawan,L Vande Walle,Kristof Kersse,Sigrid Cornelis,Sigrid Cornelis,Sofie Claerhout,Isabel Vanoverberghe,Ria Roelandt,R. De Rycke,Jelle Verspurten,Wim Declercq,Patrizia Agostinis,T Vanden Berghe,Saskia Lippens,Peter Vandenabeele +14 more
TL;DR: Findings point to a mechanism by which casp-dependent generation of Beclin-1-C creates an amplifying loop enhancing apoptosis upon growth factor withdrawal.
Journal ArticleDOI
The decision to enter mitosis: feedback and redundancy in the mitotic entry network.
TL;DR: The role of various feedback loops that regulate cyclin B–Cdk1 activation under different conditions, the timing of their activation, and the possible identity of the elusive trigger that controls mitotic entry in human cells are discussed.
Journal ArticleDOI
Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency.
Maria Barna,Aya D. Pusic,Ornella Zollo,Marco Costa,Nadya Kondrashov,Eduardo Magalhães Rego,Pulivarthi H. Rao,Davide Ruggero +7 more
TL;DR: It is demonstrated that the ability of Myc to increase protein synthesis directly augments cell size and is sufficient to accelerate cell cycle progression independently of known cell cycle targets transcriptionally regulated by Myc, and when protein synthesis is restored to normal levels, Myc-overexpressing precancerous cells are more efficiently eliminated by programmed cell death.
References
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Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.
TL;DR: By analyzing the effects of single base substitutions around the ATG initiator codon in a cloned preproinsulin gene, ACCATGG is identified as the optimal sequence for initiation by eukaryotic ribosomes.
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The scanning model for translation: an update.
TL;DR: The small (40S) subunit of eukaryotic ribosomes is believed to bind initially at the capped 5'-end of messenger RNA and then migrate, stopping at the first AUG codon in a favorable context for initiating translation.
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A family of human cdc2-related protein kinases.
Matthew Meyerson,Greg H. Enders,Chin-Lee Wu,Li-Kuo Su,C. Gorka,C. Nelson,Ed Harlow,Li-Huei Tsai +7 more
TL;DR: Ten human protein kinases based on their structural relation to p34cdc2 are identified, opening the possibility of combinatorial regulation of the cell cycle together with the emerging large family of cyclins.
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IL3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ-line configuration, and generate B lymphocytes in vivo
TL;DR: It is concluded that clones L/B AgA2, CB/Bm 7, and Bc/B m 11 are early precursors of B lymphocytes.
Journal ArticleDOI
Internal initiation of translation mediated by the 5' leader of a cellular mRNA
Dennis G. Macejak,Peter Sarnow +1 more
TL;DR: It is reported here that the 5′ leader of the binding protein mRNA can directly confer internal ribosome binding to an mRNA in mammalian cells, indicating that translation initiation by an internal Ribosome-binding mechanism is used by eukaryotic mRNAs.
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