Silas Maniatis

TL;DR: Overall, this work provides a genome-scale, quantitative resource of the impact of the loss of each host gene on fitness/response to viral infection.

TL;DR: Spatiotemporal transcriptomics in ALS spinal cord models reveals dynamics of disease-driven gene regulation and identifies pathway dynamics, distinguish regional differences between microglia and astrocyte populations at early time points, and discern perturbations in several transcriptional pathways shared between murine models of ALS and human postmortem spinal cords.

TL;DR: Binding specificity and activity determinants of the ActRIIB receptor that combine to effect specificity in the activation of distinct signaling pathways are revealed.

TL;DR: Spatially resolved transcriptomics (SRT) offers the promise of understanding cells and their modes of dysfunction in the context of intact tissues as mentioned in this paper, with a large number being published in recent years.

TL;DR: Spatial transcriptomics is used to obtain gene expression measurements of mouse spinal cords over the course of disease, as well as of postmortem tissue from ALS patients, to characterize the underlying molecular mechanisms in ALS, and reveals spatiotemporal dynamics of disease driven gene regulation.