Silke Sachse

TL;DR: It is demonstrated that OR83b heterodimerizes with conventional ORs early in the endomembrane system in OSNs, couples these complexes to the conserved ciliary trafficking pathway, and is essential to maintain the OR/OR83b complex within the sensory cilia, where odor signal transduction occurs.

TL;DR: This work identifies a functionally segregated olfactory circuit in flies that is activated exclusively by geosmin, which constitutes an ecologically relevant stimulus that alerts flies to the presence of harmful microbes.

TL;DR: The results show the presence of two separate inhibitory networks: one is GABAergic and modulates overall AL activity, the other is PTX-insensitive and glomerulus-specific, which selectively inhibit glomeruli with overlapping response profiles, in a way akin to "lateral" inhibition in other sensory systems.

TL;DR: It may be possible to create a functional atlas of the AL in which particular molecular receptive ranges are attributed to each glomerulus, based on measured glomerular responses to 30 different odors in the AL of honeybees.

TL;DR: Optically measured glomerular calcium activities in vivo in the honeybee Apis mellifera during olfactory stimulation with 36 pure chemicals differing systematically in carbon chain length and functional group (aldehyde, ketone, alcohol, carboxylic acid and alkane) to allow conclusions about the interactions between o aroma receptors and odour molecules, and about the AL network.