Silvano Junior Santini

TL;DR: Mitochondria seem to play an important role as source of ROS in both male and female reproductive systems under EMF exposure, suggesting a better understanding of molecular mechanisms underlying EMF potential challenge to the authors' reproductive system in order to improve preventive strategies.

TL;DR: The finding that up-regulation of glyoxalase 1 is associated with that of components of a Sirt1 functional network in the ovaries of MG mice provides strong evidence that SIRT1 participates in the response to methylglyoxal-dependent glycative stress in the female gonad.

TL;DR: The higher ability of PMNs of NASH patients in suppressing CD4+ and CD8+ T cells, over time, might contribute in reducing the immunological defense of liver tissue against damages thus taking part in the progression of the NAFL disease toward NASH.

TL;DR: RSV totally abolished the HG-dependent cytotoxicity, and this was associated with SIRT1 upregulation, together with increased expression of GLO1, improved ROS-scavenging efficiency, and total suppression of HG-related GS and OS.

TL;DR: In this paper, human umbilical cord endothelial cells obtained from women affected by gestational diabetes (GD-HUVECs) display durable pro-atherogenic modifications and might be considered a valid in vitro model for studying chronic hyperglycemia effects on early endothelial senescence.