S
Silvia E. Asis
Researcher at University of Buenos Aires
Publications - 31
Citations - 354
Silvia E. Asis is an academic researcher from University of Buenos Aires. The author has contributed to research in topics: Quinoline & Catalysis. The author has an hindex of 9, co-authored 30 publications receiving 306 citations.
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Journal ArticleDOI
Microwave-assisted Friedländer synthesis of quinolines derivatives as potential antiparasitic agents
TL;DR: A series of substituted quinolines was developed via the Friedlander reaction employing microwave irradiation (MW), in the presence of a catalytic amount of hydrochloric acid.
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Design, synthesis and evaluation of acridine and fused-quinoline derivatives as potential anti-tuberculosis agents.
TL;DR: The cyclopenta[b]quinoline derivative 9 and the acridine derivative 13 showed remarkable MIC values against the rifampin resistant strain and can be considered a new lead compound.
Journal ArticleDOI
Synthesis, trypanocidal activity and molecular modeling studies of 2-alkylaminomethylquinoline derivatives.
Gisela Celeste Muscia,Silvia I. Cazorla,Fernanda M. Frank,Gabriela L. Borosky,Graciela Buldain,Silvia E. Asis,Emilio L. Malchiodi +6 more
TL;DR: Six analogous derivatives of a quinoline derivative substituted by a 2-piperidylmethyl moiety showed remarkable improvement in activity against epimastigotes, trypomastsigotes and amastigote compared with the structure lead, as well as a good selectivity index for the two parasite stages present in humans.
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Microwave-assisted Döbner Synthesis of 2-Phenylquinoline-4-carboxylic Acids and their Antiparasitic Activities
TL;DR: A series of twelve substituted 2-phenylquinoline-4-carboxylic acids analogous to antimalarial and antileishmanial natural products was developed via the Dobner reaction employing microwave irradiation and evaluated in vitro against the parasites responsible for malaria, leishmaniasis and trypanosomiasis diseases.
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Diarylsemicarbazones: synthesis, antineoplastic activity and topoisomerase I inhibition assay.
Silvia E. Asis,Ana M. Bruno,Andrea R. Martinez,Marı́a V. Sevilla,Carlos H. Gaozza,A. Romano,Jorge D. Coussio,G. Ciccia +7 more
TL;DR: A series of diarylsemicarbazones synthesized and tested against human neoplastic cell lines demonstrated linear correlation between lypophilicity and activity on the most sensitive lines and a definite conformational shape for antineoplastic action.